中西医结合治疗特应性皮炎的临床观察  

Clinical Study on Treatment of Atopic Dermatitis by Integrated Traditional Chinese and Western Medicine

作　　者：史永俭[1] 张春敏[1] 马冬梅[1] 刘瑛[1] 张冬云[1] 张春红[1] 魏国[1] 孟丽亚[1] 

机构地区：[1]山东大学第二医院皮肤科,济南250033

出　　处：《中国中西医结合杂志》2008年第8期686-688,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察中西医结合治疗特异性皮炎的临床疗效及其作用机制。方法将47例特异性皮炎患者随机分为中西医结合组和西药组。西药组单纯口服氯雷他定10mg,每天1次。中西医结合组在西药组治疗基础上合并加味当归饮加减治疗,疗程4周。并用双抗体夹心ELISA法检测两组患者治疗前后外周血白细胞介素4、10、12(IL-4、IL-10、IL-12)水平。结果中西医结合组愈显率56%(14/25例),西药组为22.7%(5/22例),两组比较,差异有统计学意义(χ2=5.38,P<0.05)。治疗前两组患者与健康对照组比较,IL-4、10水平升高,IL-12水平降低(均P<0.01);治疗后中西医结合组3种细胞因子水平恢复正常,西药组无明显变化。两组比较,差异有统计学意义(P<0.01)。结论中西医结合治疗特应性皮炎疗效肯定,其作用机制可能与调节相关细胞因子水平有关。Objective To observe the clinical effects and explore the mechanism of the integrated traditional Chinese and Western medicine in treating atopic dermatitis （AD）. Methods Forty-seven patients with AD were randomly assigned to two groups, the control group and the treated group, they were treated with conventional Western medicine （10rag Loratadine tablet, once daily ） and with integrated medicine additionally given modified Jiawei Danggui Detection besides Western medicine respectively for 4 weeks. Double-sandwich ELISA was used to detect the levels of interleukin- 4, -10 and -12 （ IL- 4, IL-10 and IL-12） before and after treatment. Results The total effective rate in the treated group was 56% （ 14/25 cases） , better than that in the control group （22.7% , 5/ 22 cases）, showing significant difference between the two groups （ X2 = 5.38, P 〈 0. 05 ）. Before treatment the ser- um levels of IL- 4, IL-10 were significantly higher and level of IL-12 was lower in AD patients as compared with those in healthy persons （P 〈 0.01 ） ; they all restored to normal in the treated group after treatment but unchanged in the control group, showing significant difference between the two groups （ P 〈 0. 01 ）. Conclusion The clinical effect of integrated traditional Chinese and Western medicine is ascertainable, its mechanism might be associated with the regulation on related cytokines.

关 键 词：特应性皮炎 细胞因子 中西医结合 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]