排毒保肾丸治疗慢性肾功能衰竭的临床观察  

Effect of Paidu Baoshen Pill in Retarding the Progression of Chronic Renal Failure

作　　者：王水华 邓宏韬 王国斌 吴兆东 陈邦明 吴景芳 

机构地区：[1]江西省九江市中医医院,江西332000

出　　处：《中国中西医结合杂志》2008年第8期735-738,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：江西省卫生厅中医药基金项目(No.04A56)

摘　　要：目的评估排毒保肾丸(即大黄虫丸加减)对延缓慢性肾功能衰竭(chronicrenalfailure,CRF)2、3期进程的影响。方法将283例慢性肾衰2、3期患者分为2组,治疗组151例(用排毒保肾丸3g,每天2次口服治疗);对照组132例(用包醛氧化淀粉酶胶囊每次5～10粒,每日3次餐后服);两组均2个月为1个疗程,治疗1、2个疗程后观察生活质量、临床症状评分及血清肌酐、尿素氮、内生肌酐清除率指标变化。结果两组临床症状积分、生活质量评分比较差异有统计学意义(t值分别为29.49、9.8,P<0.01)。治疗组总有效率70.86%(107/151例),对照组总有效率44.70%(59/132例),两组比较差异有统计学意义(χ2=18.69,P<0.01),治疗前两组血清肌酐、尿素氮、内生肌酐清除率比较,差异无统计学意义(P<0.05);治疗1、2个疗程后两组比较,差异有统计学意义(P<0.05,P<0.01)。结论排毒保肾丸对延缓慢性肾功能衰竭进程有效,能提高患者生活质量。Objective To assess the impact of Paidu Baoshen Pill （ PBP, modified Dahuang Zhechong Pill）, in retarding the procession of chronic renal failure （CRF） of stage Ⅱ -Ⅲ. Methods The 283 patients of CRF stage Ⅱ -Ⅲ were randomly assigned to two groups, 151 patients in the treatment group treated with oral administra- tion of PBP 3 g twice a day, and 132 patients in the control group with oxidative amylase aldehyde enveloped capsule 5 -10 capsules thrice a day after meal. The course for both groups was 2 months, and the changes after 1 or 2 courses treatment in scoring of quality of life （QOL） and clinical symptoms, also in laboratory indexes including se- rum levels of creatinine （Cr）, urea nitrogen （UN）, and intrinsic creatinine clearance rate were observed. Results The total effective rate was 70. 86% （ 107/151 cases） in the treatment group and 44. 70% （59/132 cases） in the control group, showing significant difference between them （X2 = 18.69, P 〈 0. 01 ）. Significant differences between groups were also shown in comparisons of scores of QOL and clinical symptoms after treatment. Inter-group comparison showed no difference in all the three indexes detected before treatment, but they did show statistical sig- nificance respectively after 1 and 2 courses of treatment （ P 〈 0. 05 and P 〈 0.01 ）. Conclusion PBP could effec- tively retard the progression of chronic renal failure and significantly improve the QOL of patients.

关 键 词：排毒保肾丸 慢性肾功能衰竭 临床观察 

分 类 号：R277.5[医药卫生—中医学]