探讨雷公藤对血栓闭塞性脉管炎的初步影响  

Explored Tripterygium Wilfordii to effects of thromboangiitis obliterans in initial

作　　者：张建勇[1] 于中丽[1] 

机构地区：[1]新疆医科大学附属中医医院普外科,新疆乌鲁木齐830000

出　　处：《新疆医科大学学报》2008年第6期701-702,705,共3页Journal of Xinjiang Medical University

摘　　要：目的:探讨雷公藤对血栓闭塞性脉管炎(TAO)的初步影响。方法:将研究对象随机分为两组,即TAO实验组与对照组,每组12例。实验组采用雷公藤+基础治疗45 d,对照组基础治疗45 d。比较两组治疗前、后血清白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)、趾端皮肤温度(TTS)及MRI下肢动脉流出道检查显影分数(OTVC)差异。结果:TAO实验组与对照组治疗前血清IL-1、TNF-α、TTS及OTVC差异无统计学意义(P>0.05)。治疗后第45天血清IL-1、TNF-α及TTS差异均有统计学意义(P<0.05),TAO实验组及对照组病例OTVC差异无统计学意义。结论:雷公藤对TAO血清IL-1、TNF-α有抑制作用,对缺血肢体动脉侧支再生有一定的影响,可提高缺血趾端皮肤温度。Objective：To explore effects of Tripterygium Wilfordii（TP） to thromboangiitis obliterans（TAO）in initial.Methods：Experimental and control group of TAO were used of study： there were 12 cases in each of the group,experimental group of TAO was treated by TP＋basic treatment in 45 days.The control group was treated by basic treatment in same days.It was taken by variance analysis on interleukin-1（IL-1） and tumor necrosis factor-a（TNF-α） and temperature of toes skin（TTS） and outflow tract of visualization score（OTVC） in MRI for the two groups at prior-treatment and post-treatment.Results： Differences were non-significant（P〉0.05） in experimental and control group on IL-1 and TNF-α and TTS and OTVC at the prior-treatment.At post-treatment 45 days,the differences were significant（P〈0.05） in the two groups on IL-1 and TNF-α and TTS.The all cases in each group,differences were some significant on OTVC of MRI.Conclusions：TP can inhibit from IL-1 and TNF-α on TAO,and reconstruct branch of arterial lower extremity,and raise temperature of ischemic toes also.

关 键 词：雷公藤 血栓闭塞性脉管炎 影响 

分 类 号：R654.4[医药卫生—外科学] R285.5[医药卫生—临床医学]