美托洛尔与地尔硫卓治疗心肌反复梗塞效果的比较  

Effect of metoprolol compared with diltiazem in patients with myocardium infarction repeatedly

作　　者：朱元州[1] 冯义柏[2] 姚晋涛 

机构地区：[1]武汉科技大学附属医院心内科,湖北武汉430064 [2]华中科技大学同济医学院附属协和医院 [3]武汉市石化医院

出　　处：《心血管康复医学杂志》2008年第4期376-378,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:比较美托洛尔与地尔硫卓治疗心肌反复梗塞病人的疗效。方法:44例急性心肌反复梗塞患者随机分成两组,一组给予美托洛尔6.25mg,口服,1次/d,另一组给地尔硫卓30mg,口服,1次/d。疗程均为1个月。结果:两组患者短期死亡率没有明显差别(P>0.05),美托洛尔组的疼痛症状缓解,疼痛再发和心衰的减少均显著优于地尔硫卓组(P<0.05)。结论:小剂量美托洛尔选择性阻断β1受体,降低心肌的耗氧量,有对抗儿茶酚胺的心脏毒性作用,在防止心肌梗塞的面积扩大和改善症状方面优于地硫尔卓,其长期效果仍需继续观察。Objective： To investigate the effect of metoprolol compared with diltiazem in patients with myocardium Infarction repeatedly. Methods： The 44 patients with repeated myocardium infarction randomly divided into two groups. The metoprolol group applies 6.25mg metoprolol, 2 times/d. The diltiazem group applies 30mg diltiazem, 3 times/d. Course of treatment was a month all. Results： There was no significant difference between two groups about the death rate of short-term （P〉0.05）. The symptomatic relief of pain and pain recur attack, heart failure decrease in metoprolol group were more than those of diltiazem group （P〈0. 05 all）. Conclusion： Minidose metoprolol can improve symptoms and decreases heart failure.

关 键 词：美托洛尔 地尔硫卓 心肌梗塞 

分 类 号：R542.22[医药卫生—心血管疾病]