盐酸替罗非班对急诊经皮冠状动脉介入治疗无再流现象的影响  

Effects of tirofiban on no-reflow in patients with acute myocardial infarction during emergency percutaneous coronary intervention

作　　者：陈大鹏[1] 沙勇[1] 贾绍斌[1] 何琳[1] 曾永柱[1] 张亮[1] 

机构地区：[1]宁夏医学院附属医院心内科,宁夏银川750004

出　　处：《心血管康复医学杂志》2008年第4期378-380,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的：观察盐酸替罗非班对ST段抬高急性心肌梗塞（STEMI）患者急诊经皮冠状动脉介入治疗（PCD中血流的影响。方法：一选择急诊入院STEMI患者43名，随机分为盐酸替罗非班组23例和对照组20例。替罗非班组PCI术前开始应用盐酸替罗非班，持续泵人至术后36-48h。对照组应用常规PCI。收集所有病例的临床及冠状动脉造影资料，观察PCI术前、术后血流情况。结果：替罗非班组急诊PCI术后TIMI血流3级的发生率（94％）较对照组（89％）显著增加（P〈0．05）。结论：替罗非班可改善STEMI患好梗塞相关血管的TIMI血流。Objective： To investigate the effects of tirofiban on no-reflow in patients with ST segment elevation acute myocardial infarction （STEMI） during emergency percutaneous coronary intervention （PCI）. Methods： Forty-three patients with STEMI who underwent emergency PCI were randomly divided into tirofiban group （n= 23） and control group （n= 20）. Tirofiban was used in the former group before operation and continued for 36-48 h after PCI. In the latter group, PCI was performed through routine process. The TIMI flow before and after the operation was reviewed by angiography. Results： Ninety-four percent patients in the tirofiban group were recovered with TIM 3 grade flow; it was more than that in the control group （89%）, P〈0.05. Conclusion： Tirofiban may improve TIMI flow in patients with STEMI during emergency PCl.

关 键 词：替罗非班 血管成形术 经腔 经皮冠状动脉 冠状动脉疾病 

分 类 号：R541.4[医药卫生—心血管疾病]