2型糖尿病并发TIA患者凝血状态临床研究  

Blood Coagulation State in Diabetes Mellitus Complicated with Transient Ischemic Attack

作　　者：唐晓科[1] 杨弘文[1] 

机构地区：[1]南华大学附属第一医院神经内科,湖南衡阳421001

出　　处：《社区医学杂志》2008年第15期1-3,共3页Journal Of Community Medicine

摘　　要：目的通过研究2型糖尿病并发TIA患者凝血状态,探讨预后与高凝状态的关系,以指导TIA的治疗。方法选择2型糖尿病并发TIA患者86例,对照组TIA患者80例,健康对照组40例。以酶联免疫吸附法测定3组患者血浆血管性假血友病因子、D-二聚体、凝血酶原片段1和2、可溶性纤维蛋白单体复合物等凝血分子标志物的含量并进行比较,并随访1年,比较预后。结果TIA患者(对照组)血浆血管性假血友病因子、D-二聚体、凝血酶原片段1和2、可溶性纤维蛋白单体复合物较健康对照组均升高(P<0.05);TIA合并2型糖尿病患者(DM组)各项指标较对照组均升高(P<0.05)。3组死亡率比较差异有显著性,DM组最高(P<0.05)。结论提示高凝状态与糖尿病合并TIA有密切关系,可预测该类患者的预后。Objective To investigate the relationship between blood coagulation state and prognosis in diabetes mellitus（DM） complicated with transient ischemic attack（TIA）.Methods Enzyme Linked Immuno Sorbent Assay（ELISA） was used to measure the level of plasma vWF,D-D,F1 ＋ 2 and SFMC in 86 cases with DM complicated with TIA（test group）,compared with 80 cases with TIA（control group）,and compared with 80 cases with health（health control group）.Results Results showed the concentrations of plasma plasma vWF、D-D、F1＋2 and SFMC in test group were significantly higher than in control group（P〈0.05）.Conclusion These suggest there is closed relationship between prothrombotic state and DM complicated with TIA.

关 键 词：TIA 2型糖尿病 凝血状态 

分 类 号：R587.23[医药卫生—内分泌]