血管紧张素Ⅱ的Ⅰ型受体基因中Al166C多态性位点与急性心肌梗塞相关性研究  

No Association between the Polymorphism Al166C of the Angiotensin Ⅱ R Type 1 Receptor and the risk of Acute Myocardial Infarction

作　　者：翟莉[1] 吕豪[1] 王玉[1] 王京[1] 萧洒 张英[1] 刘建春[1] 

机构地区：[1]武警北京总队第二医院心内科,100037

出　　处：《中国分子心脏病学杂志》2008年第4期214-216,共3页Molecular Cardiology of China

摘　　要：目的研究咀管紧张素ⅡR的Ⅰ型受体基因(angiotensinⅡR type 1 receptor,AT1R)的多态性位点Al166C与急性心肌梗塞发生风险的关系。方法采用聚合酶链式反应-限制酶片段长度多态性(PCR-RFLP)技术,对96例急性心肌梗塞患者和96例正常对照个体进行分型。结果在病例组与对照组间Al166C位点的基因型和等位型频率均无显著差异(P>0.05)。结论AT1R基因的Al166C多态性位点对急性心肌梗塞的发生风险不产生影响。Objective To study the relationship between the polymorphism A1166C of the angiotensin Ⅱ R type 1 receptor （AT1R） gene and the risk of acute myocardial infarction. Methods The study group comprised 96 patients with their first acute anterior myocardial infarction （MI） and 96 healthy control subjects. The polymorphism A1166C was determined using polymerase chain reaction amplification and restriction fragment length polymorphism analysis. Results No significant difference was detected in either the genotype distribution or allele frequencies between the patients and the controls for the AT1R A1166C. Conclusions The results suggest that the A1166C polymorphism of AT1R did not influence the risk of acute MI.

关 键 词：基因多态性 心机梗塞 AT1R基因 

分 类 号：R542.22[医药卫生—心血管疾病] R544.1[医药卫生—内科学]