动脉粥样硬化炎症靶向的MR分子影像学  

Inflammation-targeted MR molecular imaging in atherosclerosis disease

作　　者：赵瑞(综述)[1] 邓钢(审校)[1] 

机构地区：[1]东南大学临床医学院,东南大学附属中大医院放射科,江苏南京210009

出　　处：《医学研究生学报》2008年第8期868-871,876,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金资助项目(批准号:30770264/C03031801)

摘　　要：动脉粥样硬化是慢性炎性血管疾病,许多炎性细胞和分子参与斑块的形成及发展。斑块的组成成分决定斑块的易损或不稳定型,MRI能在分子和细胞水平评价斑块的成分,进而区分易损斑块与不稳定型斑块,并可体内检测抗动脉粥样硬化的治疗效果。现就易损斑块特异性的炎症靶向分子成像进展作一综述。Atherosclerosis, as a chronic inflammatory vascular disease, involves many cellular and molecular events in its formation and progression from an early fatty streak lesion to a highly dangerous rupture-prone plaque. The vulnerability Or destabilization of atherosclerotic plaques is closely associated with plaque composition. Such imaging modality as magnetic resonance imaging （MRI）, which allows of the evaluation of the plaque composition at the cellular and molecular level, may differentiate vulnerable and destabilized plaques and monitor the efficacy of antiatherosclerotic therapies. This paper gives an overview of molecular imaging strategies currently used for targeting the inflammation markers of atherosclerotic plaque vulnerability.

关 键 词：分子影像学 动脉粥样硬化 磁共振显像 炎症 

分 类 号：R543.5[医药卫生—心血管疾病]