地塞米松和格拉司琼预防腹腔镜胆囊切除术后恶心呕吐比较的研究  

Comparison of dexamethasone and granisetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

作　　者：卜祥梅[1] 戚晓良[2] 王舟[3] 于文滨[4] 王志刚[2] 

机构地区：[1]山东大学医学院,山东济南250012 [2]山东大学第二医院麻醉科,山东济南250033 [3]山东大学齐鲁医院麻醉科,山东济南250012 [4]山东大学第二医院普外科,山东济南250033

出　　处：《中国现代普通外科进展》2008年第4期287-289,共3页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:研究地塞米松和格拉司琼预防腹腔镜胆囊切除术后恶心呕吐的临床效果及两者有无交互作用。方法:80例ASAⅠ～Ⅱ级择期全身麻醉下行腹腔镜胆囊切除术的患者,随机分为4组:地塞米松组、格拉司琼组、地塞米松+格拉司琼组和对照组,每组20人。各组患者均于麻醉诱导前经静脉给予止吐药,记录术后24h内恶心呕吐评分及刀口愈合情况。结果:各实验组术后恶心呕吐评分均低于对照组(P<0.05);地塞米松组和格拉司琼组相比差异无统计学意义(P>0.05);地塞米松+格拉司琼组与格拉司琼组、地塞米松组相比均降低(P<0.05);析因分析认为地塞米松和格拉司琼两药联合应用对预防术后恶心呕吐具有协同作用;各组术后刀口愈合均良好。结论:地塞米松和格拉司琼均能较好预防术后恶心呕吐,两者效果无明显差异,两药联合应用具有协同作用。Objective： To compare dexamethasone and granisetron for the prevention of PONV （Postoperative nausea and vomiting） after LC （Laparoscopic cholecystemy）. Methods： Atotal of 80 patients were randomly divided into four groups （n= 20 each）. A： dexamethasone 8 mg group; B： granisetron 3 mg, C： combined application group,D were the control group. All patients were given the similiar standardized anesthesia and operative treatment. PONV were assessed during the first 24 h after operations. Resuslts： Group A,B and C got higher scores of PONV than the control group（P〈 0,05）. Both group A and B got lower scores of PONA than group C（P〈 0.05）. But there were no statistical significance between group A and B. The two drugs had interaction when used combined. Conclusion： Either dexamethasone or granisetron decreases the incidence and degree of PONV after LC. And the two drugs can enhance curative effect each other.

关 键 词：胆囊切除术 腹腔镜 手术后恶心呕吐 地塞米松 格拉司琼 

分 类 号：R619.9[医药卫生—外科学]