基于Amira的OSAS动物模型阻塞形态可视化研究  

Visualization research of obstructive morphology in OSAS animal upper airway based on amira

作　　者：张小军[1] 刘永义[2] 刘丹[1] 李晓阳[1] 刘有军[3] 

机构地区：[1]北京工业大学机械工程与应用电子技术学院,北京100022 [2]中国人民解放军第359医院,江苏镇江212001 [3]北京工业大学生命科学与生物工程中心,北京100022

出　　处：《北京生物医学工程》2008年第4期358-361,共4页Beijing Biomedical Engineering

基　　金：国家自然科学基金(10372010;10272112)资助

摘　　要：上气道组织结构异常诱发的气道狭窄,是OSAS病人发生阻塞性呼吸暂停的病理学基础。通过动物实验,建立猪的OSAS模型,结合数字图像处理技术以及三维重建方法,从形态学上观测OSAS动物模型上气道阻塞部位及其形态。结果发现,模型猪在出现常见的OSAS表现30天之后,在其上气道鼻腔部位观测到明显的阻塞形态。表明建立的OSAS动物模型不仅可行,而且有效,能为OSAS力学仿真模型的建立以及OSAS疾病的临床诊治提供可靠基础。Anomalous structural tissue in morphology of airway probably induces constrictive obstruction, which is considered as the pathological base of OSAS in obstructive apnea. The OSAS model of pig is presented according to animal experiments. Furthermore,obstructive region and obstructive morphology in OSAS airway are visualized using digital image processi,g and 3-dimensional reconstruction. The results show that obstructive morphology is visible distinctly in the region of nasal cavity 30 days later after the pig was planted in OSAS. So this animal model with OSAS is not only feasible but also effective,which helps to the establishment of simulation dynamic model and clinical treatment in OSAS.

关 键 词：OSAS 动物模型 三维重建 可视化 

分 类 号：R318.01[医药卫生—生物医学工程]