甲亢患者血、尿β_2-M及尿Alb测定的临床意义  

The clinical significance of measurement of serum,urine β_2-microglobulin and urine albium in patients with hyperthyroidism

作　　者：陶林[1] 段东[1] 李建国[1] 朱玉泉[1] 

机构地区：[1]重庆医科大学附属第一医院核医学科,重庆400016

出　　处：《重庆医科大学学报》2008年第7期893-894,共2页Journal of Chongqing Medical University

摘　　要：目的:探讨测定甲亢患者血、尿微球蛋白(β2-microglobulin,β2-M)及尿白蛋白(Albium,Alb)的临床意义。方法:采用放射免疫分析法(Radioimmunoassay,RIA)法测定50例健康志愿者及190例甲亢患者血、尿β2-M及尿Alb水平,并对血清T3、T4、Cre、Urea进行同步检测,进行对比分析。结果:血、尿β2-M水平及尿Alb水平甲亢初诊组与未缓解组均明显高于对照组及甲亢治愈组(P<0.01),甲亢未缓解组明显高于初诊组(P<0.01),甲亢治愈组与对照组无显著性差异(P>0.05)。甲亢组患者血清β2-M水平与甲状腺激素水平具有良好的相关性(相关系数为0.91)。结论:联合检测血、尿β2-M及尿Alb对于判断患者甲亢病情及早期诊断肾脏损伤的部位和程度具有一定的临床意义。Objective：To study the clinical value of t of serum, urine β2-microglobulin （ β 2-M ） ） and urine albium in patients with hyperthyroidism. Methods：The levels of serum β2-M,thyroid hormone （including T3,T4）,Cre,Urea and urine β2-M,and albium of 50 healthy volunteers（as control group） and 190 patients with hyperthyroidism were measured by radioimmunassay（RIA）.And the results were compared and analyzed. Results：Levels of serum β2-microglobulin and urine β2-microglobulin,and albium in the patients with hyperthyroidism （including the preliminary diagnosis group and unrelieved group） were significantly higher than those in control group and cured hyperthyroidism group（P〈0.01 ）;those were significantly higher in unrelieved group than those in preliminary diagnosis group with hyperthyroidism（P〈0.01 ）,and there was no significant difference between the control group and cured hyperthyroidism group in serum β2-M and urine β2-M,and albium（P〉0.05）. There was favourable correlation between the serum β2-microglobulin and serum T3（the correlative coefficient was 0.91 ）. Conclusion：It is of great clinical significance to measure serum and urineβ2-microglobulin combinding urine albium for concluding the degree of hyperthyroidism,as well as the location and degree of the damages of kedney.

关 键 词：甲亢 Β2-微球蛋白 尿白蛋白 肾功能 

分 类 号：R581[医药卫生—内分泌]