复方环丙沙星栓剂的制备及其含量测定  

Preparation and Determination of Compound Ciprofloxacin Suppository

作　　者：姜赛平[1] 陈建[1] 卢晓阳[1] 叶轶青[2] 

机构地区：[1]浙江大学医学院附属第一医院,杭州310003 [2]浙江大学医学院附属妇产科医院,杭州310006

出　　处：《中国现代应用药学》2008年第4期350-352,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的制备环丙沙星一奥硝唑复方栓剂并建立其含量测定方法。方法以PEG400，PEG6000为基质，熔融法制备环丙沙星-奥硝唑复方栓剂，采用高效液相色谱法进行含量测定。结果制备得到水溶性基质的环丙沙星-奥硝唑复方栓剂；环丙沙星在41．6～416μg·mL^-1浓度范围内线性关系良好（r=0．9991），平均回收率为（98．45±0．51％）％；奥硝唑在43—430μg·mL^-1浓度范围内线性关系良好（r=0．9996），平均回收率为（98．70±0．49）％。结论该制备工艺简单，含量测定方法操作简便，测定结果准确可靠，可用于复方环丙沙星栓剂的质量控制。OBJECTIVE To prepare ciprofloxacin-ornidazole suppository and establish an HPLC method for content determination. METHODS PEG 400 and PEG6000 were used as suppository base and the drug concentration was determined by HPLC. RESULTS The suppository was prepared with ornidazole and ciprofloxacin as main ingredient, and water-soluble base as materials. The linear rang of ciprofloxacin and omidazole were 41.6 - 460 μg · mL^ -1 （ r = 0. 999 1 ） and 43 - 430 μg · mL^ -1 （ r = 0. 999 6）, respectively. The average recovery rates of ciprofloxacin and ornidazole were （ 98.45 ± 0.51 ） % and （ 98.70 ± 0.49 ） %, respectively. CONCLUSION The preparation technique is simple, the determination method is rapid, simple and accurate, and can be used for the quality control of suppository.

关 键 词：环丙沙星 奥硝唑 栓剂 高效液相色谱法 

分 类 号：R944.23[医药卫生—药剂学] R917.795[医药卫生—药学]