2型糖尿病患者尿MMP-9排泄水平的变化  

Change in urinary matrix metalloproteinase-9 excretion in patients with type 2 diabetes mellitus

作　　者：徐将[1] 叶山东[1] 姚新明[1] 郑茂[1] 赵俐丽[1] 钱燕[1] 孙致连[1] 李素梅[1] 

机构地区：[1]安徽医科大学附属省立医院内分泌科,合肥230001

出　　处：《安徽医科大学学报》2008年第4期426-429,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金项目(编号:01041181)

摘　　要：目的探讨2型糖尿病患者中尿基质金属蛋白酶-9（MMP-9）排泄的变化及其临床意义。方法测定88例糖尿病患者和28例正常对照尿MMP-9和尿肌酐（Ucr）比值。2型糖尿病患者据其24h尿白蛋白排泄率（UAER）分为3组：正常蛋白尿组：UAER〈20μg／min，28例；微量蛋白尿组：UAER20～200μg／min，32例；临床蛋白尿组：UAER〉200μg／min，28例。结果与正常对照组比较，糖尿病患者各组尿MMP-9／Ucr明显增高，差异有显著性（P〈0．05）。糖尿病患者正常蛋白尿组尿MMP-9／Ucr比值已升高（P〈0．05），并且随肾脏病情加重进一步增高（P〈0．01）。相关分析显示：糖尿病患者尿MMP-9／Ucr比值与尿白蛋白／Ucr比值（r=0．566，P〈0．01）和尿视黄醇结合蛋白（RBP）／Ucr比值（r=0．692，P〈0．01）呈正相关。结论糖尿病患者尿MMP-9排泄增加与肾脏病变程度有关，尿MMP-9排泄增加可能间接反映糖尿病肾组织MMP-9合成和表达增加。Objective To investigate the changes in urinary matrix metalloproteinase-9 （MMP-9） excretion in patients with type 2 diabetes mellitus. Methods Urinary MMP-9 and creatinine were measured in 88 patients with type 2 diabetes mellitus and 28 control subjects. The diabetic patients were divided into 3 groups according to urinary albumin excretion rate （ UAER ） ： （ 1 ） normal albuminuria group, UAER 〈 20 μg/min, n = 28 ; （ 2 ） microalbuminuria group, UAER 20 - 200 μg/min, n = 32 ; （3） macroalbuminuria group, UAER 〉 200 μg/min, n = 28. Results Compared with that in the control group, the ratio of urinary MMP-9/urinary creatininr （Ucr） increased significantly （ P 〈 0.05 ） in diabetes patients. Urinary MMP-9/Ucr had already increased significantly in patients with normal albuminuria （P 〈 0. 05 ） and further rosed as the nephropathy progressed （P 〈 0. 01 ）. Urinary MMP-9/UCr was positively related to urinary albumin/Ucr （ r = 0. 566, P 〈 0. 01 ） and urinary retinal binding protein/UCr（r =0. 692,P 〈 0. 01 ）. Conclusion Urinary MMP-9 excretion increased in type 2 diabetics, which is related to the degree of diabetic nephropathy; Increased urinary MMP-9 excretion may reflect the increased expression and synthesis of renal tissue of diabetics.

关 键 词：糖尿病肾病/尿 基质金属蛋白酶类/尿 视黄醇结合蛋白质类/尿 蛋白尿 

分 类 号：R587.1[医药卫生—内分泌] R345.9[医药卫生—内科学]