臭氧加胶原酶注射治疗腰椎间盘突出症疗效观察  

Curative effect of combined injections of ozone and collagenase in the treatment of lumbar disc herniation

作　　者：武春银[1] 陈家骅[1] 王松[1] 

机构地区：[1]安徽医科大学第一附属医院疼痛科,合肥230022

出　　处：《安徽医科大学学报》2008年第4期452-455,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省卫生厅科研基金资助项目(编号:002A021)

摘　　要：目的观察CT引导下臭氧加胶原酶联合注射治疗腰椎间盘突出症的临床疗效。方法150例腰椎间盘突出症患者根据治疗方法不同分为两组:Ⅰ组(76例)经皮穿刺在CT引导下椎间盘内和突出物内注射臭氧加胶原酶,Ⅱ组(74例)在椎间盘内和突出物内注射胶原酶。术后7、30d比较两组疗效。临床疗效评价标准分为三级:显效、有效及无效。结果治疗后7dⅠ、Ⅱ组的有效率分别为85.5%(65/76)、67.6%(50/74),30d的有效率分别为93.4%(71/76)、91.9%(68/74)。两组治疗后7d时有效率差异有显著性(P<0.05),30d时有效率差异无显著性(P>0.05)。结论联合注射臭氧加胶原酶治疗腰椎间盘突出症的近期疗效明显优于单纯注射胶原酶,远期疗效差异无显著性。Objective To observe the clinical efficacy of CT-guided combined injections of ozone and collagenase in the treatment of lumbar disc herniation （LDH）. Methods 150 patients were divided into two groups. Group 1 of 76 patients were treated with ozone and collagenase and group 2 with 74 patients were injected with only collagenase. Then these two groups were observed on the seventh and thirtieth day after the treatment respectively. Results On the seventh day, the effective rate was 85.5% （65/76） in group 1 and 67.6% （50/74） in group 2 respectively; while on the thirtieth day, the effective rate of group 1 was 93.4% （71/76） and that of group 2 was 91.9% （68/71）. The difference in the curative effect between the two groups was statistically significant （ P 〈0. 05 ） on the seventh day but not on thirtieth day （P 〉 0. 05 ）. Conclusion The curative effect of combined treatment of ozone and collagenase is better than singular collagenase treatment in short-term.

关 键 词：椎间盘移位/治疗 胶原酶类/投药和剂量 臭氧/投药和剂量 腰椎 

分 类 号：R681.53[医药卫生—骨科学] R916.3[医药卫生—外科学]