尿碘与尿氟的相关性分析  

RESEARCH ON CORRELATION OF URINARY IODINE AND URINARY FLUORIDE

作　　者：周伯钦[1] 王武林[1] 庄景凡[1] 

机构地区：[1]湖南省常德市常德职业技术学院,常德415000

出　　处：《现代预防医学》2008年第17期3411-3412,共2页Modern Preventive Medicine

摘　　要：[目的]通过对缺碘地区碘缺乏病人服用碘制剂后与当地健康人(未服碘制剂)的研究,分析尿碘与尿氟在排出的尿中是否存在相互关系。[方法]取正在服用碘制剂的单纯性甲状腺肿与克汀病病人26例(实验组),当地未服碘制剂的正常人24例(对照组),测定尿碘与尿氟。[结果]实验组与对照组尿碘均值分别为(126.5±25.8)μg/L和(87.1±27.1)μg/L,P﹤0.01;尿氟平均值分别为(0.37±0.11)mg/L和(0.57±0.13)mg/L,P﹤0.01,尿碘与尿氟的相关系数r=-0.723。[结论]服用碘制剂的单纯性甲状腺肿与克汀病病人的尿碘高于当地未服碘制剂的正常人,尿氟低于未服碘制剂的正常人,尿碘与尿氟排出存在负相关,碘与氟在肾脏的排出有相互抑制作用。[Objective] Through researching on iodine-deficiency patients who take iodine and healthy people who don＇t take iodine respectively in iodine-deficiency area, to analyze whether there is relative relationship between urinary iodine and urinary fluoride in urine. [Methods] Took 26 people with simple goiter or with cretinism as experimental group and 24 healthy people as control group, measured their urinary iodine and urinary fluoride. [Results ] The average of urinary iodine of experimental group and control group was （126.5±25.8） μg/L and （87.1 ±27.1 ）μg/L. P 〈 0.01 respectively, while the average of urinary fluoride was （0.37±0.11） mg/L and （0.57±0.13） mg/L respectively. The correlation coefficient of urinary iodine and urinary fluoride was r=-0.723. [Conclusions] The average level of urinary iodine of people with simple goiter or with cretinism who take iodine is higher than healthy people who don＇t take iodine, however, as for urinary fluoride, the average level of which of people with simple goiter or with cretinsm taking iodine is lower than healthy people without taking iodine. So it indicates that urinary iodine and urinary fluoride negatively correlate to each other. From this result, we conclude there is competition between urinary iodine and urinary fluoride when they are discharged in human.

关 键 词：尿碘 尿氟 相关性分析 

分 类 号：R446.12[医药卫生—诊断学]