内皮细胞损伤及尿微量蛋白与糖尿病视网膜病变的相关性研究  

STUDY OF THE RELATIONSHIP OF VASCULAR ENDOTHELIAL CELL INJURY AND MINIMAL PROTEIN OF URINARY AND DIABETIC RETINOPATHY

作　　者：王芳[1] 徐莉[1] 

机构地区：[1]河南大学东京临床学院检验科,开封475009

出　　处：《现代预防医学》2008年第17期3435-3436,3442,共3页Modern Preventive Medicine

基　　金：河南省科技攻关基金资助项目(0424410102)

摘　　要：[目的]探讨糖尿病视网膜病变(DR)不同时期血浆血管性血友病因子抗原(vWF:Ag)、尿微量白蛋白排泄率(UAER)及尿转铁蛋白(UTRF)的变化,探讨糖尿病视网膜病变(DR)的发生机理,以寻找早期筛选DR的指标。[方法]129例2型糖尿病患者分无视网膜病变组(NDR)71例、背景期视网膜病变组(BDR)39例和增殖期视网膜病变组(PDR)19例,采用速率散射比浊法检测UAER和UTRF,酶联免疫吸附双抗体夹心法(ELISA)测定vWF:Ag,同时设健康体检者60人为对照组。[结果]3组糖尿病患者vWF:Ag、UAER和UTRF水平均高于对照组(P﹤0.01)。UAER与UTRF二种检测方法结果差异有统计学意义(P﹤0.01),UTRF灵敏度高于UAER。[结论]检测vWF:Ag、UAER和UTRF对早期发现糖尿病视网膜病变有重要意义。[Objective] To investigate the levels ofvon willebrand factor： antigen （vWF： Ag）, Urinary albumin excretion rate （UAER） and urinary transferring （UTRF） in different stages of DR and their implication. [Methods] 129 cases with type 2 diabetes patients were divided into three groups： no diabetic retinopathy group （NDR） 71 cases, background diabetic retinopathy group （BDR） 39 and proliferative diabetic retinopathy group （PDR） 19. UAER and UTRF were measured by rate nephelometry method, vWF： Ag was measured by ELISA. [ Results] The serum levels of vWF： Ag, UAER and UTRF in patients with NDR, BDR and PDR were higher than those in control group （P 〈 0.01 ）. Between UAER and UTRF, there was a significant difference （P 〈 0.01 ）, UTRF was higher than UAER. [Conclusion] Detection of vWF： Ag, UAER and UTRF is very important for early discovery of diabetic retinopathy.

关 键 词：糖尿病视网膜病变 内皮损伤 尿微量白蛋白 尿转铁蛋白 

分 类 号：R587.1[医药卫生—内分泌]