4种中药防治高原脱适应的效果  

EFFECTS OF FOUR CHINESE MEDICINES ON PREVENTION AND TREATMENT OF DEACCLIMATIZATION TO HIGH ALTITUDE

作　　者：张西洲 崔建华 李彬 王宏运 马广全 张泉龙 

机构地区：[1]兰州军区第十八医院高山病研究所,新疆叶城844900

出　　处：《解放军预防医学杂志》2008年第4期250-253,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：兰州军区医药卫生科研计划资助项目课题(No.CXH-2005023)

摘　　要：目的观察复方党参、复方红景天等4种中药复方防治高原脱适应的效果。方法对驻守海拔5 170 m 1年的57名健康青年随机分为5组:银杏叶片组(12人);复方红景天组(12人);刺五加组(11人);复方党参组(11人);对照组(11人)。采用单盲方法进行实验。自返回平原前第5天药物组开始分别口服上述药物,对照组口服炒面胶囊,直至返回平原后第7天,共服药12 d。采用高原脱适应症状调查表随访返回平原后第24、、6天的脱适应症状。返回平原后第7天清晨采静脉血检测MDAS、OD、NO及NOS的水平;心理生理测试仪测试左右手交叉敲击动作频率和数字记忆广度顺背数;二级定量负荷踏阶运动实验评价PWC170和台阶指数。结果脱适应症状得分复方党参组返回平原第2、4、6天(1.73±0.79、1.36±0.67、0.91±0.54)和复方红景天组返回平原第4、6天(1.67±0.89、1.25±0.87)较对照组(2.82±1.17、3.18±1.78、2.09±0.70)减少(P<0.05或P<0.01);与对照组比较,银杏叶片组、复方红景天组和复方党参组MDA均降低,NO、NOS增高,银杏叶片组和复方党参组SOD增高(P<0.05或P<0.01);与对照组比较,复方党参组左右手交叉敲击动作频率总次数和正确次数增加(P<0.05),平均每次敲击时间减少(P<0.05);复方党参组和复方红景天组数字记忆广度顺背数测验得分较对照组增高(P<0.05);复方党参组和复方红景天组PWC170(196.9±13.3和197.6±29.4)较对照组(175.0±13.60)增高(P<0.05),台阶指数(62.69±9.69和62.07±3.30)较对照组(54.59±7.17)增高(P<0.05)。结论复方党参胶囊和复方红景天胶囊防治高原脱适应效果较好。Objective To observe the effects of four Chinese medicines on prevention and treatment of deacclimatization to high altitude. Methods Fifty-seven healthy soldiers stayed at 5 170m altitude for one year were randomly divided inte 5 groups： Gingkgo biloba（ n = 12）, Rhodiola compound （ n = 12）, Acanthopanax tablet （ n = 11）, Dang- shen compound （n = 11 ）, and placebo（ n = 11 ）. Single blind trial was used in this experiment. The subjects took medicine for 5 d before retum to sea level and continued taking for 7 d after arrived at plain The questionnaire of symptom of deacclimatization to high altitude was used on the 2nd, 4th, 6th d after returned to sea level. The levi of MDA, SOD, NO and NOS in blood serum on 7th d morning after arrived at plain were measured. A neuropsychological monitoring system was used to record total frequency of hands cross movement and memory of order number test. PWC170 and step index were also evaluated. Results The score of symptom of deacclimatization in Dangshen compound group on 2nd, 4th, 6th d after reurned to sea level （ 1.73 ± 0.79, 1.36 ± 0.67, 0.91 ± 0.54 respectively） and that in Rhodiola group on 4th, 6th d （1.67±0.89,1.25±0.870） were lower than that in control group（2.82 ± 1.17,3.18± 1.78,2.09 ± 0.70）, （ P 〈 0.01, or P 〈 0.05）. The content of MDA in Gingkgo biloba, Rhodiola compound, Dangshen compound groups were lower while the level of NO, NOS were higher than in control group. SOD in Gingkgo biloba and Dangshen group compound were higher too. The total times and right times of hands cross frequency in Dangshen compound group were higher, and the average time of every beat was shorter. The score of memory-span of order number test both in Dangshen compound and rhodiola groups was higher than in control group （ P 〈 0.05）. The PWC170 and step index in Dangshen compound group （196.9± 13.3,62.69 ± 9.69） and Rhodiola group （197.6 ± 29.4,62.07 ± 3.30） were higher than those in control group （ 175.0 ± 13.6,54.5

关 键 词：高原 脱适应 复方党参 复方红景天 

分 类 号：R135.6[医药卫生—劳动卫生]