2-乙硫基-β-萘并噻唑乙替硫酸-酯盐合成的研究  

Study on synthesis of 2-ethylmercapto-β-naphthothiazole etho-ethylsulfate

作　　者：王小刚[1] 

机构地区：[1]西北大学化工学院,陕西西安710069

出　　处：《应用化工》2008年第8期861-864,共4页Applied Chemical Industry

基　　金：陕西省自然科学基金项目(96H07)

摘　　要：以α-萘胺为起始原料，通过封管反应、碱提取、水蒸气蒸馏、乙酸酸化和乙醇重结晶，取得了纯度较高的2-巯基-β-萘并噻唑。研究发现，2-巯基-β-萘并噻唑与PdCl2有高灵敏度、高选择性的络合显色作用，并把这种显色方法成功地用于该噻唑的提纯检验上。对2-乙硫基-β-萘并噻唑的物态提出了不同看法，得到IR谱的证明。最终在2-乙硫基-β-萘并噻唑与硫酸二乙酯摩尔比1：1．5～1：1．8，反应温度110～130℃的优化反应条件下成功合成了2-乙硫基-β-萘并噻唑乙替硫酸-酯盐，产率34％，m．P．52～54℃。The high purity of 2-mereapto-β-naphthothiazole was obtained with α-naphthylamine as raw material via reaction of seal glass tube, alkaline extraction, vapor distillation, acidification of acetic acid and ethanol recrystallization. The research displays a chromogenic complex action of high sensitivity and better selectivity with PdCl2, the chromogenic method was applied to the purification and test of naphthothiazole successfully. A different view for the physical state of 2-ethylmereapto-β-naphthothiazole was presented, which was proved by IR spectrum. 2-Ethylmercapto-β-naphthothiazole etho-ethylsulfate was successfully synthesized under the conditions of molar ratio of 2-ethylmereapto-β-naphothiazole to ethyl sulfate 1 ： 1.5 ～ 1 ： 1.8 and reaction temperature 110 ～ 130 ℃ . The yield of product is 34% ,m. p. 52 ～54 ℃.

关 键 词：2-乙硫基-β-萘并噻唑乙替硫酸-酯盐 合成 机理 

分 类 号：TQ614.4[化学工程—精细化工]