甘草酸对肺纤维化模型大鼠羟脯氨酸、玻璃酸、层粘连蛋白的干预作用  

Interventional Effect of Glycyrrhizin on Hydroxyproline,Hyaluronic Acid,and Laminin in Pulmonary Fibrosis Model Rats

作　　者：吕小华[1] 吴铁[1] 覃冬云[1] 

机构地区：[1]广东医学院药理学教研室,湛江市524023

出　　处：《中国药房》2008年第25期1954-1955,共2页China Pharmacy

摘　　要：目的:研究甘草酸对肺纤维化模型大鼠羟脯氨酸(HYP)、玻璃酸(HA)、层粘连蛋白(LN)含量的影响。方法:80只SD大鼠随机分为正常对照组、模型组、激素组(强的松0.6mg·kg·d-1)和甘草酸(10g·kg·d-1)组,后3组用博来霉素建立大鼠肺纤维化模型,造模后第2天各组给予相应试药(正常对照组和模型组给予等容生理盐水),观察用药第7、28天后各组肺组织中HYP及血清中HA、LN含量变化。结果:与模型组比较,甘草酸组肺组织HYP和血清中HA、LN的含量明显降低(P<0.05)。结论:甘草酸对肺纤维化有一定的治疗作用。OBJECTIVE： To observe the effects of glycyrrhizin on hydroxyproline （HYP）, hyaluronic acid （HA） and laminin （LN） in pulmonary fibrosis model rats. METHODS： A total of 80 SD rats were randomly divided into normal control group, model group, hormone group （prednisone 0.6 mg ·kg·d^-1）, and glycyrrhizin group （10 g ·kg·d^-1） . The latter 3 groups were established into pulmonary fibrosis model with bleomycin, and on the second day after modelling, each group was given corresponding test drugs （the normal group and model group were treated with same amount of normal saline） then the changes of the levels of HYP in lung tissues, and serum levels of HA and LN in every group were observed at 7 and 28 days respectively. RESULTS： In glycyrrhizin group compared with model group, the contents of HYP in lung tissue, HA and LN in serum decreased significantly （P〈0.05）. CONCLUSION： Glycyrrhizin has been proved to be of curative effect on pulmonary fibrosis.

关 键 词：甘草酸 肺纤维化 大鼠 玻璃酸 层粘连蛋白 

分 类 号：R965[医药卫生—药理学] R975.5[医药卫生—药学]