载脂蛋白E基因多态性和运动与血脂异常的关系  

On Relationship of Apolipoprotein E Gene Polymorphisms and Exercise to Dyslipidemia

作　　者：张慧敏[1] 

机构地区：[1]德州学院体育系,山东德州253023

出　　处：《菏泽学院学报》2008年第2期75-79,共5页Journal of Heze University

摘　　要：载脂蛋白E有ApoE2、ApoE3和ApoE4三种主要的异构体,有2ε、3ε和4ε三种常见的等位基因,其基因编码可形成ApoE2/2、ApoE3/3、ApoE4/4三种纯合子表型和ApoE3/2、ApoE4/3、ApoE2/4三种杂合子表型.不同种族间载脂蛋白E等位基因的频率和基因型频率都不同.载脂蛋白E基因多态性是个体间血脂水平差异的常见遗传因素,与个体间血脂代谢和血脂异常的发生存在一定的关联.此外,载脂蛋白E基因多态性可调节运动对血脂的影响,但其机制还有待于进一步的研究.Apolipoprotein E has three major Iso forms including ApoE2, ApoE3 and ApoE4, three major ApoE Iso forms are encolded by three alleles which are ε2, ε3 and ε4. Its six genotypes are ApoE2/2, ApoE3/3, ApoE4/4, ApoE3/2, ApoE4/3 and ApoE2/4. Gene frequency and genotype frequency are different in nationalities. Apolipoprotein E ,gene polymorphism is significantly correlated with serum lipid level. Beyond, apolipoprotein E, gene polymor- phism is related to the effect which exercise affects blood lipids.

关 键 词：载脂蛋白E 基因多态性 运动 血脂异常 

分 类 号：G804.3[文化科学—运动人体科学]