血小板生成素在慢性乙型肝炎血小板减少症中的作用  

The role of thrombopoietin in chronic hepatitis B patients with thrombocytopenia

作　　者：谭斌[1] 何伟锋[1] 许岸高[1] 温帆渊[1] 

机构地区：[1]惠州市中心医院消化内科肝病区,广东惠州516001

出　　处：《中西医结合肝病杂志》2008年第4期216-217,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：惠州市科技计划项目课题(No.44011120060309)

摘　　要：目的:探讨血小板生成素在慢性乙型肝炎血小板减少症患者中的作用。方法:对76例慢性乙型肝炎血小板减少症患者进行血清血小板生成素水平、凝血酶原活动度、骨髓巨核细胞计数检查。结果:血小板生成素水平与凝血酶原活动度、骨髓巨核细胞计数、外周血小板计数相关(r分别为0.423、0.396、0.297,P<0.05);76例患者标本中有22例骨髓巨核细胞计数<7(个/4.5 cm2),占20%;巨核细胞成熟障碍29例,占38%。结论:血小板生成素在慢性乙型肝炎血小板减少症的发病机制中起一定作用。Objective： To explore the role of thrombopoietin in chronic hepatitis B patients with thrombocytopenia. Methods： The serum thrombopoietin levels, prothrombin activity, bone marrow megakaryocyte count were measured in 76 chronic hepatitis B patients with thrombocytopenia. Results： The serum thrombopoietin levels were correlated with parameters including coagulation activation, bone marrow megakaryocyte count, the platelet count （ r was 0.423, 0. 396, 0. 297 respectively, P 〈 0.05） . The bone marrow megakaryocyte count was below （7/4.5cm^2 ） in 22 out of 76 patients. Megakaryocyte was dysmaturity in 29 out of 76 patients. Conclusion： The results suggest that decline of thromhopoietin may contribute to thrombocytopenia in chronic hepatitis B patients.

关 键 词：肝炎 乙型 慢性 血小板生成素 巨核细胞 血小板减少症 

分 类 号：R512.62[医药卫生—内科学] R55[医药卫生—临床医学]