乙酰半胱氨酸泡腾颗粒中有关物质的测定  

Determination of Related Substances in Acetylcysteine Effervescent Granules

作　　者：王正俊[1,2] 周春燕[1,2] 

机构地区：[1]南京中医药大学,江苏南京210029 [2]南京蓝本科技有限公司,江苏南京210029

出　　处：《中国药业》2008年第17期12-13,共2页China Pharmaceuticals

摘　　要：目的测定乙酰半胱氨酸泡腾颗粒中的有关物质。方法采用高效液相色谱(HPLC)法,用十八烷基硅烷键合硅胶为填充剂,以磷酸调pH至3.0的乙腈-水(3∶97)为流动相,检测波长为220nm。结果乙酰半胱氨酸泡腾颗粒中的有关物质与乙酰半胱氨酸能较好地分离。结论HPLC法简便、专属性强,适用于乙酰半胱氨酸泡腾颗粒中有关物质的检查。Objective To determine the related substances in acetylcysteine effervescent granules by HPLC. Methods The Hypersil C18 eolunm was used with the mobile phase of aeetonitrile （adjusted to pH 3.0 with phosphoric acid） - H2O （3 ： 97） at the detection wavelength of 220 nm. Results Under the optimal condition, a good separation was achieved for acetyleysteine and the related substances. Conclusion This simple and selective method can be successfully used to determine the related substances in acetylcysteine effervescent granules.

关 键 词：乙酰半胱氧酸 有关物质 高效液相色谱法 

分 类 号：R927.11[医药卫生—药学] R974.1