快速微波热声层析成像在生物医学中的潜在应用  

Fast Microwave-induced Thermoacoustic Tomography and the Application in Biomedicine

作　　者：娄存广[1] 邢达[1] 聂立铭[1] 

机构地区：[1]华南师范大学激光生命科学研究所暨激光生命科学教育部重点实验室,广东广州510631

出　　处：《激光生物学报》2008年第4期530-534,529,共6页Acta Laser Biology Sinica

基　　金：国家自然科学基金项目(30470494;30627003);广东省自然科学基金项目(7117865)

摘　　要：介绍了一种快速热声层析成像方法和装置,成功实现了生物组织的二维热声层析成像及异物检测。实验中采用频率为1.2 GHz的脉冲微波作为激发源,中心频率为3.5 MHz的320振元线性阵列探测器接收热声信号,然后用有限场滤波反投影方法重建得到热声层析图像。与原有方法相比,勿需全方位扫描采集数据,能大量节省时间,重建图像的对比度和抗噪声能力有极大提高。该方法和系统有望应用于乳腺癌早期检测、体内异物检测、微波热疗效果监测等方面。A thermoacoustic tomography system was developed and used to reconstruct tissue image and detect foreign body. The frequency of the microwave used in the system is 1.2 GHz. The microwave absorption image can be reconstructed through signals received by the 320 transducer elements with mid-frequency 3, 5 MHz, A phase-controlled focus technique is used to reduce data acquisition time and a limited-field-fihered back-projection algorithm is used to enhance spatial resolution and signal to noise rate. This system has a potential to use in the detection of early breast tumor, foreign body and microwave thermotherapy effect monitoring,

关 键 词：热声成像 异物检测 肿瘤早期检测 治疗监控 

分 类 号：Q684[生物学—生物物理学] R312[医药卫生—基础医学]