细胞介导免疫在小鼠抗假丝酵母菌感染中的作用  

Role of cell-mediated immunity in murine responses to Candida infection

作　　者：胡雁[1] Camile S.Farah Robert B.Ashman 

机构地区：[1]中山大学光华口腔医学院口腔生物学教研室,广东广州510055 [2]澳大利亚昆士兰大学牙学院口腔生物学研究中心

出　　处：《国际口腔医学杂志》2008年第4期411-413,共3页International Journal of Stomatology

基　　金：广东省自然科学基金资助项目(7001543)

摘　　要：细胞介导免疫是一个复杂的系列反应过程,当抗原进入机体后,抗原呈递细胞呈递抗原信息给T细胞,使之被激活后变成辅助性T细胞(CD4+)。此时,CD4细胞又可分为分泌白细胞介素-2和干扰素-γ的辅助性T细胞(Th1)及分泌白细胞介素-10的辅助性T细胞(Th2)。在假丝酵母菌感染时,Th1反应激活中性粒细胞和巨噬细胞,促进宿主抗假丝酵母菌;Th2反应则抑制宿主的抗感染作用。细胞介导免疫在系统性假丝酵母菌感染中的作用一直存在争议,但在口腔黏膜抗假丝酵母菌感染中的作用是肯定的。The cell-mediated immune （CMI） response involves a complex series of events after antigens enter the body. First, the antigen must be taken up by macrophages or/and dendritic cells and presented to T cells, which become activated as T-helper（CD4 cells） or cytotoxic T cells（CD8 cells）. CD4 cells are classified into two subgroups： Th1 cells, that secrete predominantly interleukin（IL）-2 and interferon-γ; and Th2 cells, that secrete predominantly IL-4, IL-5, and IL-10. These cytokine secretion profiles distinguish the so-called Th1 or Th2 responses to antigen stimulation. Th1 responses activate nentrophils and macrophages to a candidacidal activity, whereas Th2 responses tend to inhibit a fungicidal state in Candida infection. There is general consensus that CMI is essential for the protection of mucosal tissues from Candida infection although the function of T cells in systemic candidiasis remains contentious.

关 键 词：细胞介导免疫 假丝酵母菌 感染 小鼠 

分 类 号：R519[医药卫生—内科学]