原发性高血压患者血浆内皮素与内源性类洋地黄物质的变化  

STUDY ON CHANGS OF PLASMA ENDOTHELIN AND ENDOGENOUS DIGOXIN-LIKE SUBSTANCE LEVELS IN PATIENTS WITH ESSENTIAL HYERTENSION

作　　者：徐有奇[1] 周文[1] 兰进军[1] 田玉静[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所核医学科,630042

出　　处：《放射免疫学杂志》1997年第5期263-265,共3页Journal of Radioimmanology

摘　　要：本文采用放射免疫分析法,对71例高血压患者和35例正常人血浆内皮素(ET)与内源性类洋地黄物质(EDLS)的含量进行检测。结果表明,高血压组血浆ET与EDLS含量明显高于正常血压组(p<0.01),血浆ET与EDLS之间呈显著正相关(r=0.53,p<0.001)。血浆ET与EDLS含量随血压增高及病程延长逐渐升高。EH组中血浆ET与EDLS含量Ⅱ期高于Ⅰ期。以上结果提示:血浆ET与EDLS在高血压病的发生发展过程中起重要作用。Plasma levels of endothelin (ET) and endogenous digoxin-like substance (EDLS) were measured with radioimmunoassay in 71 patients with essential hypertension(EH) and 35 healthy subjcts. The EH group had higher levels of ET and EDLS (p<0.01) than those in the controls.Plasma ET and EDLSlevels at stage, Ⅱ of EH were significantly higher (p<0.01)than those at stage Ⅰ,A positive correlation was found between the levels of plasma ET and EDLS(p<0.01). The data suggested that the levels of plasma ET andEDLS might play an important role in the development of hypertension.

关 键 词：高血压 原发性 内皮素 内源性类 洋地黄物质 

分 类 号：R544.1[医药卫生—心血管疾病]