血栓素与6-酮-前列腺素F_1α含量测定在肾移植急性排斥中的临床意义  

CLINICAL SIGNIFICANCE OF DETERMINATION OF PIASMA AND URINE TXB_2 AND 6-KETO-PGF_1α IN ACUTE REJECTION AFTER RENAL TRANSPLANTATION

作　　者：薛昭卿[1] 谢森[1] 王念龙 罗淑萍 陈之航[1] 

机构地区：[1]南京军区福州总医院,350025

出　　处：《放射免疫学杂志》1997年第6期335-337,共3页Journal of Radioimmanology

摘　　要：通过14例肾移植患者术后第3、6、9、14、28天动态监测尿液血栓素(TXB_2)与6-酮-前列腺素F_(1α)(6-Keto-PGF_(1α))含量及TXB_2/6-Keto-PGF_(1α)比值的变化观察。结果术后第3天尿TXB_2含量达467±146ng/24h,显著高于对照组(p<0.01),术后2周降至正常,而尿6-Keto-PGF_(1α)的含量呈缓慢上升趋势,第4周显著升高至与对照组同水平,尿液TXB_2/6-Keto-PGF_(1α)比值也逐渐变小。 急性排斥发生后,尿、血TXB_2含量都明显升高,与对照组比较相差显著(p<0.O1),但尿TXB_2增高早于血浆,尿TXB_2含量变化能更早、更客观地反映移植肾TXB_2的合成水平。尿、血TXB_2/6-Keto-PGF_(1α)比值变化和TXB_2一致。At 3, 6, 9, 14 and 28 days after renal transplantation, plasma and urine TXB2, 6-Keto-PGF1α levels and the ratio TXB2/6-Keto-PGF1α were determi-ned by RIA in 14 patients. The results showed that mean value of urine TXB2 levels was 467±146ng/24h at 3rd day after operation, being signi-ficantly higher than that in the control group, and returned to normal at 2 weeks. Urine 6-Keto-PGF1α level rose slowly after operation from a low value, approaching that of contral group at 4 weeks, thus the urine TXB2/6-Keto-PGF1α declined gradually.In patients with acute rejection, both plasma and urine TXB2 level rose to significantly higher than those in control group (p<0.01). Urine TXB2 rose earlier than plasma TXB2, so the change in urine TXB2 level might be a more sensltive and more objective index of TXB2 synthesis of the transplanted kidney. The ratio of TXB2/6-Keto-PGF1α both in plasma and urine changed as the TXB2 level changed accordingly.

关 键 词：肾移植 排斥 血栓素 6-酮-前列腺素 

分 类 号：R699.2[医药卫生—泌尿科学]