鼠曲草提取物对四氯化碳所致小鼠急性肝损伤保护作用  

Protective Effect of Gnaphalium tranzschelii against Acute Liver Injury in Mice

作　　者：姜丽君[1] 朴锦花[1] 刘宇[1] 具光梅[1] 贲亮[1] 李镐[1,2] 

机构地区：[1]延边大学药学院,吉林延吉133000 [2]长白山生物功能因子省部共建教育部重点实验室,延边大学,吉林延吉133002

出　　处：《时珍国医国药》2008年第8期1901-1902,共2页Lishizhen Medicine and Materia Medica Research

基　　金：长白山生物功能因子省部共建教育部重点实验室开放课题(No.2006071);延边大学教育基金会科研项目[延大研科合字(2007)第11号]

摘　　要：目的研究鼠曲草提取物对四氯化碳所致小鼠急性肝损伤的保护作用。方法给动物灌胃给药,用四氯化碳造小鼠急性肝损伤模型,用比色分析法测定小鼠血清天冬氨酸转氨酶(aspartate transaminase,AST)、丙氨酸氨基转移酶(ala-nine transaminase,ALT)活性、肝组织谷胱甘肽过氧化物酶(glutathione perioxidase,GSH-Px)活性和丙二醛(malondialde-hyde,MDA)含量。结果鼠曲草提取物能显著降低四氯化碳所致小鼠各组血清AST和ALT含量的升高(P<0.05),同时能升高肝组织GSH-Px的活性,降低肝组织MDA的含量(P<0.05)。结论鼠曲草提取物对四氯化碳所致小鼠急性肝损伤具有一定的保护作用。Objective To investigate the protective effect of Gnaphalium tranzschelii Kirp. against carbon tetrachloride - induced acute liver injury in mice. Methods The acute hepatic injury model was prepared by the subcutaneous injection of carbon tetrachloride in mice. The activities of ALT and AST in serum, the content of MDA and the activity of GSH - Px in liver cell were investigated by colorimetric method. Results The extract of G. tranzschelii significantly decreased the levels of ALT and AST in serum and the content of MDA, but elevated the activity content of GSH - Px in liver. Conclusion G. tranzschelii extract can prevent the acute liver injury induced by CC14 in mice through its antioxidation.

关 键 词：鼠曲草 急性肝损伤 保护作用 

分 类 号：R285.5[医药卫生—中药学]