尖吻蝮蛇毒无出血活性纤溶酶的急性毒性实验  

Experimental Study on Acute Toxicity of Non-hemorrhagic Fibrinolytic Enzyme from Agkistrodon acutus

作　　者：彭均华[1] 黎渊弘[2] 邝晓聪[1] 雷丹青[3] 黎肇炎[3] 

机构地区：[1]广西医科大学,广西南宁530021 [2]广西医科大学第一附属医院,广西南宁530021 [3]广西医科大学蛇毒研究所,广西南宁530021

出　　处：《时珍国医国药》2008年第8期1905-1906,共2页Lishizhen Medicine and Materia Medica Research

基　　金：广西科学研究与技术开发项目资助(桂科攻No.0143050)

摘　　要：目的研究无出血活性纤溶酶(Non-hemorrhagic fibrinolytic enzyme,NHFLE)的急性毒性,评价其安全性。方法尾静脉注射给药,观察记录给予NHFLE后昆明种小鼠的急性毒性反应。结果NHFLE的半数致死量(LD50)为28.84 mg/kg。结论急性毒性实验证实该药毒性低,临床应用安全性好。Objective To evaluate the safety of non -hemorrhagie fibrinolytie enzyme（NHFLE） from Agkistrodon acutus by aeute toxieity researeh. Methods The aeute toxieity of NHFLE was studied on Kunming speeies miee by venous injeetion. Results Aeute toxieity experiment showed that LD50 of NHFLE was 28.84 mg/kg in miee. Conclusion Aeute toxieity study indieated that NHFLE has low toxieity and it is safe in clinical application.

关 键 词：蛇毒 尖吻蝮蛇 纤溶酶 急性毒性实验 

分 类 号：R965.3[医药卫生—药理学]