神经信号转导功能与慢性阻塞性肺疾病的关系  

Relation of nerve signal transduction function and chronic obstructive pulmonary disease

作　　者：王孝微[1] 刘凤岐[1] 

机构地区：[1]哈尔滨医科大学附属第一医院心血管内科,150001

出　　处：《国际呼吸杂志》2008年第16期1005-1008,共4页International Journal of Respiration

摘　　要：慢性阻塞性肺疾病是全球范围内主要的慢性疾病和死亡原因。近年来随着分子生物学研究的进展，神经内分泌功能在疾病中的作用不断被揭示，慢性阻塞性肺疾病存在着交感神经过度激活、β肾上腺素能受体功能下调、胆碱能神经受体分布异常等广泛的自主神经功能异常。Chronic obstructive pulmonary disease is ordinary chronic disease and primary death cause in the world. In recent years,because of progression of molecular biology,neuroendocrine system involved in various diseases has been. revealed continually. Extensive dysfunctions of autonomic nerve are presented in chronic obstructive pulmonary disease, such as excessive activation of sympathetic fiber, depression of beta- adrenoceptor function and abnormal distribution of cholinergic receptor.

关 键 词：慢性阻塞性肺疾病 肾上腺素能 胆碱能 非肾上腺素非胆碱能 受体 环磷酸腺苷 

分 类 号：R563[医药卫生—呼吸系统] R338[医药卫生—内科学]