核因子-κB在神经干细胞增殖和分化中的作用  

Roles of Nuclear Factor-κB on the Proliferation and Differentiation in Neural Stem Cells

作　　者：刘玉霞[1] 汪泱[1] 邓志锋[2] 

机构地区：[1]南昌大学第一附属医院泌尿外科研究所,330006 [2]南昌大学第二附属医院神经外科,330006

出　　处：《中华脑血管病杂志（电子版）》2008年第4期205-209,共5页Chinese Journal of Cerebrovascular Diseases(Electronic Edition)

基　　金：国家自然科学基金资助项目(No30560156);江西省自然科学基金资助项目(No0540087)

摘　　要：核因子-κB(NF-κB)是一种可诱导的转录因子。在神经系统中,NF-κB由神经元、神经胶质细胞和神经干细胞表达。神经干细胞具有强大的增殖能力和多向分化潜能,在神经系统损伤的修复中起重要作用。近年来的研究发现,NF-κB信号系统参与了中枢神经系统神经干细胞增殖和分化的调控,通过对其机制的深入研究,有望为脑缺血、脑炎、神经变性等疾病的治疗开辟新的途径。文章对NF-κB在神经干细胞增殖和分化中的多重作用进行了综述。Nuclear factor-KB （NF-KB） is an inducible transcription factor. In the nervous system, NF-KB is expressed by neurons, glial cells and neural stem cells. Neural stem cells have great proliferation ability and multiple differentiation potential. They play an important role in regeneration after nervous system injury. Recent studies have found that the NF-KB signal system involves in the regulation of neural stem cell proliferation and differentiation of central nervous system. It is hopeful to explore a new approach for the treatment of cerebral ischemia, encephalitis and neural degeneration through the further study on its mechanism. This article reviews the multiple effects of the NF-KB in neural stem cell proliferation and differentiation.

关 键 词：核因子-ΚB 神经干细胞 增殖 分化 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]