双氢青蒿素软膏处方筛选及体外渗透性研究  

Preparation and In Vitro Permeability Study of Dihydroartemisinin Ointment

作　　者：杜丰[1,2] 李荣生[3] 王乃婕[1] 邱琳[1] 张蓓[1] 梁秉文[1] 付桂兰[1] 叶祖光[1] 

机构地区：[1]中药复方新药开发国家工程研究中心,北京100075 [2]贵阳中医学院,贵州贵阳550002 [3]中国中医科学院实验药厂,北京100700

出　　处：《中国中医药信息杂志》2008年第9期49-50,89,共3页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的筛选双氢青蒿素(DHA)软膏处方及促渗剂。方法建立体外经皮渗透试验方法,采用高效液相色谱法对DHA样品的体外透皮速率进行考察,并以DHA累积透过量作体外透皮曲线,与Higuchi方程进行拟合。结果透皮速率以卡波普水溶性软膏及促渗剂为氮酮的最高,达到27.262μg/(h·cm2),Higuchi方程线性较好。结论最佳处方为卡波普水溶性基质的DHA软膏处方,最佳促渗剂为氮酮。Objective To optimize the formulation of Dihydroartemisinin ointment and study its characteristics of penetration enhancers. Method A method of transdermal experiment in vitro was established for DHA. The penetration rate in vitro was examined by HPLC, and coincided the DHA cumulative permeation curve with the Higuchi equation. Result The penetration rate of DHA from DHA ointment made up of water-soluble carbopol and Azone was the highest in all formulations, up to 27.262 pg/（h · cm^2）. The cumulative permeation curve which coincided with the Higuchi equation was better. Conclusion The formulation which made up of water-soluble carbopol and Azone was optimized.

关 键 词：双氢青蒿素 软膏 体外透皮试验 促渗剂 高效液相色谱法 

分 类 号：R283.5[医药卫生—中药学]