低分子肝素钙联合辛伐他汀治疗不稳定型心绞痛疗效观察  

Effect of low molecular weight heparin calcium and simvastatin on patients with unstable angina pectoris

作　　者：孟令波 许建功[2] 史新长 

机构地区：[1]开封市陇海医院内二科,河南开封475003 [2]新乡医学院第三附属医院胸外科,河南新乡453003

出　　处：《新乡医学院学报》2008年第5期498-500,共3页Journal of Xinxiang Medical University

摘　　要：目的观察采用低分子肝素钙联合辛伐他汀治疗不稳定型心绞痛（UA）的治疗效果。方法观察组除常规用药外，加用低分子肝素钙5000u，每12h皮下注射1次，连用7-10d，辛伐他汀20mg，每晚顿服1次，连服8周。对照组除常规用药外，另加普通肝素100mg加50g·L^-1葡萄糖溶液500mL维持静脉滴注，维持激活全血凝固时间于正常值的1．5～2倍，连用7～10d。检测2组治疗前后总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL—C）、高密度脂蛋白（HDL—C），并评定疗效。结果观察组总有效率（92％）明显高于对照组（76％）（P〈0．05）。2组治疗前TC、TG、LDL—C、HDL—C比较均无显著性差异（P〉0．05）；对照组治疗前后TC、TG、LDL—C、HDL—C比较均无显著性差异（P〉0．05）；观察组治疗后HDL—C明显升高，TC、LDL—C、TG均下降，与治疗前比较均有显著性差异（P〈0．05），与对照组治疗后比较均有显著性差异（P〈0．05）。结论采用低分子肝素钙联合辛伐他汀治疗UA效果明显，安全可靠。Objective To observe the clinical effect of low molecular weight heparin combined with simvastatin on unstable angina（UA）. Methods The patients in observation group were treated with low-molecular-weight heparin calcium 5 000 u by subcutaneous injection every 12 hours for 7 - 10 days, simvastatin 20 mg every night for 8 weeks. The patients in control group were treated with 100 mg heparin plus 50 g · L^-1 glucose solution 500 mL byintravenous infusion for 7 - 10 d. Total cholesterol（ TC）, triglyeride（ TG）, low density lipoprotein（LDL-C） and high density lipoprotein（HDL） were detected before and after treatment in two groups, and the curative effect was evaluated. Results The total efficiency was significantly higher in observation group（92% ） than this in control group （76% ,P 〈0.05）. There was no significant difference in TC,TG,LDH-C and HDL-C between two groups before treatment （ P 〉 0.05 ）. There was no significant difference in TC, TG,LDH-C and HDL-C between pretreatment and posttreatment （P 〉 0.05 ）. HDL-C was increased, TC, LDH-C and TG were decreased after treatment in observation group, There was significant difference between pretreatment and posttreatment （P 〈 0.05 ）, There was significant difference in TC. TG. LDH-C and HDL-C between two groups after treatment （ P 〈 0. 05 ）. Conclusion Low molecular weight heparin calcium and simvastatin for treatment of UA was efficiently and safe.

关 键 词：低分子肝素 辛伐他汀 不稳定型心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]