氟比洛芬酯用于腹腔镜胆囊切除术患者超前镇痛效果的观察  

Preempty Analgesic Effect of Axetil on Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystec1tomy

作　　者：曾子代 李准民[2] 

机构地区：[1]湖南省安化县人民医院麻醉科,安化413500 [2]解放军163医院麻醉科,长沙410003

出　　处：《中国医药导刊》2008年第5期723-724,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:研究不同给药时机对氟比洛芬酯用于腹腔镜胆囊切除术(LC)患者术后镇痛效果的影响。方法:40例 ASAⅠ、Ⅱ级择期行 LC 患者,随机分为两组,每组20例:A 组于麻醉诱导时静脉注入氟比洛芬酯50mg;B 组于手术结束时静脉注入氟比洛芬酯50mg。两组均于术后完全清醒时,清醒后1、2、4、8、12、24h 进行视觉模拟评分(VAS)及不良反应观察。结果:清醒后4h 内两组 VAS 比较 A 组低于 B 组(P<0.05),余时间点两组间 VAS 差异无显著性意义,两组均无明显不良反应。结论:不同给药时机影响氟比洛芬酯用于 LC 患者的术后镇痛效果,术前给药优于术后给药,提示氟比洛芬酯具有超前镇痛作用。Objective ：To study the effects of the time of flnrbiprofen axetil administration on postoperative analgesia in patienl undergoing laparoscopic cholecystectomy （ LC ）. Methods： Forty patients of LC were randomly divided into two groups with 20 case each. The patients in group A received flurbiprofen axetil 50 mg at induction of anesthesia, and in group B flurbiprofen axetfl 50 m given as operation end. Postoperative pain was assessed by visual analogue scale（VAS）. Side effects were observed as well. Results The VAS was lower in group A than in group B （ P 〈 0. 05 ）. Conclusion： Flurbiprofen axetil administered before operation or after operation may relieve postoperative pain in patients undergoing LC with a little side-effects. It is more effective to inject flurbiprei axetil before operation than after operation.

关 键 词：氟比洛芬酯 腹腔镜胆囊切除术 超前镇痛 

分 类 号：R614[医药卫生—麻醉学] R657.4[医药卫生—外科学]