瑞芬太尼复合异丙酚在小儿手术中的麻醉效果及安全性研究  

The effectiveness and safety of remifentanil-propofol in pediatric operations

作　　者：陈涛[1] 罗刚[2] 朱俊[1] 

机构地区：[1]四川大学物理科学与技术学院生命科学实验室 [2]四川省达州市第二人民医院麻醉科,达州635000

出　　处：《四川大学学报（自然科学版）》2008年第4期956-958,共3页Journal of Sichuan University(Natural Science Edition)

摘　　要：研究瑞芬太尼复合异丙酚在小儿手术中应用的安全性和有效性.通过80例择期手术的患儿随机分为K组(氯胺酮组)和R组(瑞芬太尼组),每组40例,两组先给予静脉诱导后,术中麻醉维持K组采用静脉泵注氯胺酮和异丙酚,R组用瑞芬太尼和异丙酚.观察两组用药前、后及术中的血流动力学变化,同时观察麻醉效果(用VAS方法)、麻醉苏醒等情况.结果发现:两组麻醉效果均满意,但R组术中血流动力学变化幅度,术后苏醒恢复状况均优于K组(P<0.05).在相同的麻醉效果下使用瑞芬太尼的患儿术后苏醒快,安全性佳.To study on the effectiveness and safety of the application of remifentanil-propofol in pediatric operations. Through eighty patients undergoing selective surgery were divided randomly into group K （Ketamine group） and group R （remifentanil group）, respectively with forty cases enrolled. Either group was vein induced by katamine before group K pump intravenous anaesthetized with katamine and propofol during operation and group R with remifentanil and propofol. The changes of emodynamics before and after giving the medicine and during operation, together with the effects of anesthesia （via VAS methods） and the recovery of the anesthesia, etc., were observed. It is found that the anesthesia was satisfactory for the two groups, but the change range of emodynamics as well as the status of palinesthesia and recovery after operation in group R were superior to group K（P 〈 0.05）. Remifentanil in anesthesia care of infant patients gives better palinesthesia in time terms and higher safety under the same conditions after operation.

关 键 词：瑞芬太尼 氯胺酮 异丙酚 小儿手术 

分 类 号：R96[医药卫生—药理学]