荆三棱化学成分的研究(Ⅰ)(英文)  

Chemical Study on Scirpus yagara

作　　者：康昆[1] 时育红[1] 张鹏飞[1] 李琳[1] 胡昌奇[1] 杨国勋[1] 

机构地区：[1]复旦大学药学院,上海200032

出　　处：《天然产物研究与开发》2008年第4期639-640,649,共3页Natural Product Research and Development

基　　金：Young In-vestigator Start-up Fund of School of Pharmacy,Fudan University

摘　　要：我们前期从红花锦鸡儿(Caragana rosea)中发现两个具有抗HIV活性成分scirpusin A和B(含量仅约百万分之一),为了寻找富含该化合物的新的植物资源,我们对产于黑龙江省的荆三棱(Scirpus yagara)的化学成分进行了研究,从其乙醇提取物的乙酸乙酯萃取部位分离到6个化合物。通过1HNMR分析及与对照品TLC比较,分别鉴定为:白桦醇(1),对羟基桂皮酸(2),scirpusin A(3),白藜芦醇(4),piceatannol(5)及scirpusin B(6)。其中,化合物scirpusin A和B,在该植物中含量丰富(含量分别为0.017%和0.013%)。Scirpusin A and B were identified as active agents against HIV from Caragana rosea in our previous study （yield 1 × 10^-4 % ） ： In order to find new rich resource for the two compounds,we conducted a chemical investigation of rhizome of Scirpus yagara Owhi growing in Heilongjiang Province. Six compounds were isolated from the EtOAc fraction of this plant. On the basis of ^1H NMR as well as by comparison with authentic samples, they were identified as betulin （1） ,p-hydroxy cinnamic acid （2）, scirpusin A （3）, resveratrol （4）, piceatannol （ 5）, and scirpusin B （6） respectively. Scirpusin A and B were proved to be rich in this plant （yield 01017% and 0.013% ）.

关 键 词：荆三棱 scirpusin A scirpusin B 抗HIV 

分 类 号：R284.2[医药卫生—中药学] Q946.91[医药卫生—中医学]