中老年人慢性日光性皮炎中弹性纤维相关蛋白与基质金属蛋白酶的相关性研究  

Expressions of fibrillin-1, elastin and matrix metalloproteinase-1 and -9 in chronic actinic dermatitis in elderly patients

作　　者：刘平[1] 谭升顺[1] 王琼玉[1] 张盘谏[1] 

机构地区：[1]西安交通大学第二医院皮肤科,陕西西安710004

出　　处：《南方医科大学学报》2008年第8期1354-1357,共4页Journal of Southern Medical University

基　　金：国家自然科学基金(30600764)

摘　　要：目的观察弹性纤维相关蛋白及基质金属蛋白酶-1,9(MMP-1,9)在慢性日光性皮炎中的表达,探讨慢性日光性皮炎的发病机制。方法收集23例慢性日光性皮炎患者皮损,免疫组化检测其弹性蛋白相关蛋白,MMP-1,9的表达。采用图像分析对MMP-1和MMP-9的阳性染色结果进行半定量测定。结果慢性日光性皮炎中真皮乳头层弹性蛋白表达明显减少或消失,真皮中层弹性蛋白排列紊乱,部分区域聚集。原纤维蛋白-1也在真皮网状层明显沉积。慢性日光性皮炎中MMP-1的表达升高,而MMP-9不表达。结论弹性蛋白,及原纤维蛋白-1在慢性日光性皮炎中真皮网状层明显沉积,显示MMP-1的表达升高与中慢性日光性皮炎中弹性组织变性的物质相关。MMP-9则与慢性日光性皮炎发病似乎关系不大。Objective To investigate the expressions of fibrillin-1, elastin and matrix metalloproteinase-1 and -9 （MMP-1, 9） in chronic actinic dermatitis in elderly patients and explore the pathogenesis of the disease. Methods Twenty-three patients with chronic actinic dermatitis were examined for the expressions of fibrillin-1, elastin, MMP-1, and MMP-9 with immunohistochemistry in the skin lesions. Image analysis was carried out to measure MMP-1 and MMP-9 expressions semi-quantitatively. Results In the skin lesions of patients with chronic actinic dermatitis, elastin expression was obviously reduced or absent in the papillary dermis. The elastic fibers were disorderly arranged in the reticular dermis with local aggregation in some regions. Obvious fibrillin-1 deposition was found in the reticular dermis. Increased expressions of MMP-1, but not that of MMP-9, was found in the skin lesions of the patients. Conclusions Elastin and fibrillin-1 deposition can be found in the skin lesions in patients with chronic actinic dermatitis, suggesting the association of increased MMP-1 expression with the elastic tissue degeneration in the lesions. MMP-9 does not exhibit an obvious association with the pathogenesis of chronic actinic dermatitis in elderly patients.

关 键 词：慢性日光性皮炎 弹性纤维相关蛋白 基质金属蛋白酶 

分 类 号：R758.14[医药卫生—皮肤病学与性病学]