HIV-1中和抗体疫苗研究进展  

Development of Neutralizing Antibody Based HIV/AIDS Vaccine

作　　者：李学仁[1] 阮力[1] 

机构地区：[1]中国疾病预防控制中心病毒病预防控制所,北京100052

出　　处：《中国生物工程杂志》2008年第8期110-117,共8页China Biotechnology

基　　金：国际综合性艾滋病研究项目(1U19A15191501);国家"863"计划(2003AA219080)资助项目

摘　　要：由于HIV具有与其它微生物极为不同的生物学特点,HIV疫苗的研究面临着前所未有的困难和挑战。20多年来,艾滋病疫苗研究主要采用了诱发中和抗体为主或细胞免疫为主两种策略,然而至今尚无实质性突破。诱发有效中和抗体一直是传统疫苗研发的重要策略,但HIV的高变异、多亚型等特点,使该策略在HIV疫苗研发中的应用成效甚微。近年来,一些具有广谱中和活性的HIV单抗的发现及其相应抗原表位的阐明,给HIV中和抗体疫苗的研究带来了新的希望。综合分析与评述这些进展,对于重新思考艾滋病疫苗和采用更好的策略进行艾滋病疫苗研究会有所帮助。microorganisms, Because the biology characteristic of HIV is extremely different from that of other HIV vaccine research has being faced with unprecedented difficulties and challenges. In the last 20 years, HIV vaccine research has been carried out mainly with two strategies, i. e. , neutralizing antibody based and cellular immunization based; however, substantive breakthroughs haven＇ t been achieved until now Inducing effective neutralizing antibody is always an important strategy in traditional vaccine research, but this strategy is much less efficient in HIV vaccine research because of high variation and much subtypes of HIV. In recent years, the discovery of broadly neutralizing monoclonal antibodies and elucidation of their corresponding antigen epitopes have brought new hopes for the development of neutralizing antibody based HIV vaccine. Reviewing these advancements will be helpful for reconsidering HIV vaccine development with a better strategy.

关 键 词：HIV 中和抗体 疫苗 

分 类 号：Q819[生物学—生物工程]