三苯基锡壳聚糖磷酸酯的合成、表征及其杀钉螺活性  

Synthesis,Characterization and Molluscicidal Activity of Triphenyltin Phosphorylated Chitosan

作　　者：曹佐英[1] 许海峰[1] 唐瑞仁[2] 魏望远[3] 许外[1] 

机构地区：[1]湖南理工学院化学化工系,岳阳414000 [2]中南大学化学化工学院,长沙410083 [3]湖南省血吸虫病防治所,岳阳414000

出　　处：《化学通报》2008年第7期528-532,共5页Chemistry

基　　金：湖南省自然科学基金项目(06JJ20003)资助

摘　　要：用磷酸二氢钠和尿素在稀醋酸介质中对壳聚糖(CTS)进行磷酸化改性,得到壳聚糖磷酸酯(P-CTS),然后在85%的甲醇中与三苯基氯化锡发生亲核取代反应,合成出三苯基锡壳聚糖磷酸酯(P-CTS-SnPh3),通过红外光谱、核磁共振、热分析和粉末X-射线衍射等手段表征了这些化合物。用所得产品进行杀钉螺活性试验,结果显示,当其浓度在0.5mg/L以上时,浸杀3d后,钉螺的死亡率达100%。Phosphorylated chitosan （phosphorylate-modified chitosan, P-CTS） was synthesized by the reaction of monosodium orthophosphate with urea in the presence of HAc. Triphenyltin phosphorylated chitosan （P-CTS-SnPh3） was further prepared by the nucleophilic substitution reaction of P-CTS with triphenyltin chloride in the presence of 85% CH3 OH. The compounds were characterized and analyzed by IR, NMR, TG-DTA and X-ray diffraction etc. The results of the tests of molluscicidal activity showed that the oncomelania death rate is 100% at the concentration of P-CTS-SnPh3 over 0.5mg/L and the soaking time is 3d.

关 键 词：三苯基锡壳聚糖磷酸酯 合成 表征 杀钉螺活性 

分 类 号：TQ265[化学工程—有机化工]