对房室吸收和转运模型的修正  

Modification of Compartmental Absorption and Transit (CAT) Model

作　　者：卢韵[1] 周建平[1] 姚静[1] 

机构地区：[1]中国药科大学药剂学教研室,南京210009

出　　处：《中国药学杂志》2008年第15期1180-1184,共5页Chinese Pharmaceutical Journal

摘　　要：目的对传统的房室吸收和转运(CAT)模型进行修正,拓宽了CAT模型的适用范围。方法参考CAT模型建立的方法,利用严格的数学推导,并在结合文献数据的基础上,对传统CAT模型进行修正。结果推导得到一个更为合适的CAT模型表达式并尝试建立了一个适用于大鼠的CAT模型,确定了大鼠CAT模型的房室数目为5个。结论修正后的CAT模型适用范围有所拓宽,而大鼠CAT模型更符合大鼠自身的一些生理学特征。OBJECTIVE To modify the compartmental absorption and transit （CAT） model for extended application. METHODS By referring to some literature data,the traditional CAT model was modified by mathematical decluction and the optimal compartment number of a new CAT model was determined for rat. RESULTS A more general equation of CAT model was derived, and a five compartment CAT model was used for rat. CONCLUSION The modified CAT model was applicable and the new CAT model with five compartments is consistent with the physiological feature of rat.

关 键 词：房室吸收和转运模型 模型修正 拉普拉斯变换 

分 类 号：R965.1[医药卫生—药理学]