儿童环孢素给药剂量的年龄差异  

Age Difference of Cyclosporin Dosage in Pediatric Patients

作　　者：倪韶青[1] 丁光超[1] 石淑文[1] 王珏[1] 赵正言[1] 曾苏[2] 

机构地区：[1]浙江大学医学院附属儿童医院,杭州310003 [2]浙江大学药学院,杭州310058

出　　处：《中国药学杂志》2008年第15期1194-1196,共3页Chinese Pharmaceutical Journal

基　　金：浙江省中医药科研基金项目研究计划(2005C167)

摘　　要：目的了解儿童患者环孢素(CsA)血药浓度个体差异的发生规律,为儿童合理用药服务。方法采集2002.7～2006.8间在浙江大学医学院附属儿童医院进行环孢素血药浓度监测的样本,筛选出74例供分析用,其中男35例,女39例,年龄2月～15.8岁;研究各个年龄段儿童平均给药剂量的差异。结果各个年龄段儿童的平均给药剂量具有显著差异(P=0.000)。以2.1～3岁患儿平均给药剂量最大(12.85mg·kg-1.d-1),其次为3.1～6岁(7.26mg·kg-1.d-1),1.1～2岁(6.98mg·kg-1.d-1),6.1～8(5.69mg·kg-1.d-1),8.1～12岁(5.44mg·kg-1.d-1),12.1～16岁(5.36mg·kg-1.d-1),0～1岁(5.04mg·kg-1.d-1)。结论在临床上考虑不同年龄儿童的个体发育特征,对于增加首剂量给药的有效性非常重要。OBJECTIVE To study the interindividual variability of cyclosporin blood concentration in children to promote rational medication in pediatrics. METHODS The CsA plasma concentration data in the past 4 years （2002. 7 - 2006. 8 ） were collected in Children Hospital of Zhejiang University school of medicine, Hangzhou, China. The data of 74 patients （female 39, male 35,age from 2 months to 15.7 years） were analyzed. RESULTS The daily doses to reach the target trough level was significant different among different age groups （ P = 0. 008 ）. The results were as follows 0 - 1 year, 5.04 mg· kg^-1 · d ^-1 ; 1.1 - 2 year, 6.98 mg · kg^ - 1 · d ^-1 ; 2. 1 -3 year,12. 85 mg · kg^-1 · d^-1;3.1 -6 year, 7.26 mg · kg^-1· d^-1;6,.1 -8 year, 5.69 mg· kg^-1 · d＆^-1;8.1 -12 year, 5.44 mg · kg^-1 · d^-1 ;12. 1 - 16 years, 5.36 mg · kg^-1 · d^-1. CONCLUSION The different developmental age are of great importance for the initial rational drug therapy in children. This study offers some information towards individualized therapy in children.

关 键 词：儿童 环孢素 发育 

分 类 号：R969.11[医药卫生—药理学]