桥本甲状腺炎患者血管内皮功能受损与低度炎症反应的关系  

The role of low-grade inflammation in vascular endothelial dysfunction in patients with Hashimoto's thyroiditis

作　　者：李昌林[1] 张木勋[1] 刘永健[1] 余毅恺[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院内分泌科,武汉430030

出　　处：《临床内科杂志》2008年第8期540-542,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨低水平的炎症反应在血脂正常的桥本甲状腺炎(HT)患者血管内皮功能受损中的作用。方法将58例HT患者,分为甲状腺功能正常组(甲功正常组)28例,亚临床甲状腺功能减退组(甲减组)30例,并有28例正常人(对照组)纳入本实验。空腹静脉取血检测甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、促甲状腺素(TSH)、游离甲状腺素(FT4)、游离三碘甲腺原氨酸(FT3)、甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)、一氧化氮(NO)和超敏C-反应蛋白(hs-CRP)。结果HT患者的甲功正常组、甲减组,分别与对照组比较,NO显著下降(P均<0.01),而TgAb、TPOAb、hs-CRP则显著升高(P均<0.01)。HT患者中,甲功正常组与甲减组两两比较,NO、TgAb、TPOAb、hs-CRP均没有统计学差异(P均>0.05)。结论血脂正常的HT患者存在血管内皮功能受损,可能是由于自身免疫异常的长期低水平的炎症反应,参与了HT患者的血管内皮功能损伤。Objective To observe the role of inflammatory reaction in pathogenesis of vascular endothelial dysfunction in patients with Hashimoto＇ s thyroiditis （HT）. Methods 58 HT patients with normal lipid profile, divided into euthyroidism group and subclinical hypothyroidism group, and 28 healthy volunteers were included in the study. The fasting serum of TG, TC, LDL-C, HDL-C, TSH, FF4 , FF3 , thyroglobulin antibody （TgAb）, thyroid peroxidase antibody （TPOAb）, nitric oxide （NO） and high-sensitivity C-reactive protein （hs-CRP） were assayed. Results The serum concentrations of NO in HT patients both euthyroidism group and subclinical hypothyroidism group were significantly lower than that in healthy controis （ both P 〈 0.01 ） ,while TgAb ,TPOAb and hs-CRP higher than those in healthy controls（ respectively, P 〈0.01 ）. The serum concentrations of NO,TgAb,TPOAb and hs-CRP did not differ significantly in HT patients between euthyroidism group and subclinical hypothyroidism group （respectively, P 〉 0.05 ）. Conclusion Chronic inflammation in low grade, potentially originated from autoimmune, is one of important causes to vascular endothelial dysfunction in HT patients with normal lipid profile.

关 键 词：桥本甲状腺炎 炎症 血管内皮 C-反应蛋白 一氧化氮 

分 类 号：R581.4[医药卫生—内分泌]