曲尼司特对环孢素A慢性肾毒性大鼠肾脏TGF-β1、AngⅡ及ColⅢ的影响  

Effects of tranilast on AngⅡ,TGF-β_1 and Col Ⅲ in the kidney of rats with chronic cyclosporine A nephrotoxicity

作　　者：刘其锋[1] 李莎莎[2] 罗志娟[2] 陶冶[1] 

机构地区：[1]四川大学华西医院肾脏内科, 成都市610041 [2]四川大学华西基础与法医学院免疫学教研室,成都市610041

出　　处：《实用医学杂志》2008年第18期3111-3114,共4页The Journal of Practical Medicine

摘　　要：目的:探讨曲尼司特(tranilast,TNL)对环孢素A(CsA)慢性肾毒性大鼠血清及肾脏血管紧张素Ⅱ(AngⅡ)及肾脏转化生长因子-β1(TGF-β1)、Ⅲ型胶原(ColⅢ)的影响。方法:雄性SD大鼠24只,随机分成正常对照组、模型组、TNL治疗组、安博维治疗组。采用低盐饮食加CsA 20 mg/(kg.d)灌胃的方法建立CsA慢性肾毒性肾脏模型。观察TNL对大鼠肾脏病理及肾组织Ang Ⅱ、TGF-β1、ColⅢ的影响。结果:TNL能下调CsA慢性肾毒性大鼠血清及肾组织中AngⅡ的水平及肾组织TGF-β1、ColⅢ在肾脏的表达。结论:TNL可能通过抑制AngⅡ、TGFβ1及ColⅢ的表达而发挥其抗纤维化作用。Objective To investigate the effects of tranilast （TNL） on Ang Ⅱ , TGF-β1 and Col Ⅲ expressions in serum and kidneys in rats with chronic cyclosporine A （CsA） nephrotoxicity. Methods 24 SD rats（male） were randomly divided into 4 groups： normal control group, model control group, tranilast treatment group, irbesartan treatment group. Low salt diet and CsA were administered by gastric gavage at the dose of 20 rag/（ kg· d） and the models of chronic CsA nephrotoxicity were established. The effects of TNL on pathophysiologies and Ang Ⅱ , TGF-β1, ColⅢ expressions in the kidneys were observed. Results TNL could down regulate Ang Ⅱ levels in serum and renal tissues, down regulate the TGF-β1, and Col Ⅲ expressions of renal tissues in the rats with chronic CsA nephrotoxicity. Conclusion TNL may exert anti-fibrotic effect by suppressing the expressions of Ang Ⅱ , TGF-β1, and Col Ⅲ.

关 键 词：转化生长因子β 血管紧张素Ⅱ 环孢菌素 曲尼司特慢性肾毒性 Ⅲ型胶原 

分 类 号：R96[医药卫生—药理学]