中心静脉导管留置引流并胸腔内灌注药物治疗恶性胸腔积液  

Malignant pleural effusion treated with central venous catheter pleural drainage and intrathorax infusion of drugs

作　　者：刘国建 朱春平 林岩 

机构地区：[1]南京市第三医院肿瘤科,南京210003

出　　处：《中国新药杂志》2008年第15期1342-1343,共2页Chinese Journal of New Drugs

摘　　要：目的:探讨胸腔内中心静脉导管留置引流并灌注药物治疗恶性胸腔积液的疗效。方法:对30例恶性胸腔积液患者应用中心静脉导管胸腔穿刺置管引流并胸腔内灌注顺铂(DDP)及香菇多糖注射液(LNT)每周2次,共4周。结果:30例患者完全缓解(CR)16例,部分缓解(PR)10例,有效率(CR+PR)为86.7%。毒副反应轻,主要为轻度消化道反应和一过性发热、胸痛。结论:中心静脉导管留置引流并灌注药物治疗恶性胸腔积液简便易行、相对安全,疗效显著,毒副反应小,是晚期恶性肿瘤姑息治疗的一种有效方法。Objective： To evaluate the efficacy of central venous catheter pleural drainage and intrathorax drug infusion in the treatment of malignant pleural effusion. Methods： Cancer patients with malignant pleural effusion （n = 30） were treated with central venous catheter pleural drainage and intrathorax infusion of cisplatin （DDP） combined with leutinan （ LNT）, twice a week, for 4 weeks. Results： In the 30 patients, complete response （CR） and partial response （PR） were observed in 16 and 10 patients, respectively. The overall response rate （CR ＋ PR） was 86.7%. The major side effects included mild gastrointestinal reactions, fever and chest pain. Conclusion： Central venous catheter pleural drainage and intrathorax drug infusion is effective and safe in the treatment of malignant pleural effusion. It is an effective method of palliative treatment for advanced malignant tumor, and is worth studying in the future.

关 键 词：中心静脉导管 顺铂 香菇多糖注射液 恶性胸腔积液 

分 类 号：R979.1[医药卫生—药品]