冠心病患者花生四烯酸代谢物和血小板α-颗粒膜蛋白测定的临床意义  

Clinical Implication of Detecting the levels of Arachidonic Acid Metabolites and Platelet Granular Membrane Protein of CHD Patients.

作　　者：黄培山[1] 

机构地区：[1]柳州市工人医院

出　　处：《广西医学》1997年第5期733-735,共3页Guangxi Medical Journal

摘　　要：目的：为探讨各类型冠心病发展的危险因素。方法：测定冠心病患者（１８例隐匿型冠心病，２２例不稳定型心绞痛，１１例急性心肌梗塞）和４０名正常人花生四烯酸代谢物（ＴＸＢ２和６－Ｋ－ＰＧＦ１α）以及血小板α－颗粒膜蛋白（ＧＭＰ—１４０）的含量。结果：冠心病组与对照组比较，ＴＸＢ２和ＧＭＰ—１４０明显升高，６－Ｋ－ＰＧＦ１α明显降低，均有非常显著性差异（Ｐ＜０．０１），急性心肌梗塞组或不稳定型心绞痛组（除６－Ｋ－ＰＧＦ１α外）与隐匿型冠心病组间有显著性差异（Ｐ＜０．０５）。结论：ＴＸＡ２和ＰＧＩ２平衡的失调，ＧＭＰ—１４０含量的增加将是冠心病发展恶化的危险信号。Objective:to research for the risk factors of various CHD.Method:Detect the level of acid metabolites (TXB 2 and 6 K PGF 1α ) and GMP-140 in 51 CHD (18LCH,22UA,11AMI)patients and 40 normals.Result:For CHD group,the levels of TXB 2 and GMP-140 were much significantly higher,whereas the levels of 6 K PGF 1α was much significantly lower than the normal control(P<0 01),and in the same comparing between UA (except 6 K PGF 1α ) /or AM and LCH the difference is significant(P<0 05).Coclusion:The results indicate that the imbalance of TXA 2 and PGI 2 and the increase in GMP-140 level are the risk messages of CHD exacerbating.

关 键 词：冠心病 花生四烯酸代谢 血小板 颗粒膜蛋白 

分 类 号：R541.404[医药卫生—心血管疾病]