胆汁中IL-6、TNF-α、IL-8检测对急性胆管炎诊断和严重程度的判断价值  

Value of biliary interleukin-6,tumor necrosis factor-α and interleukin-8 in the diagnosis and extent judgement of acute cholangitis

作　　者：张利霞[1] 沈云志[1] 邱全兴[1] 汪良芝[1] 秦怡[1] 

机构地区：[1]常州市第一人民医院消化内科,213003

出　　处：《国际消化病杂志》2008年第4期348-350,共3页International Journal of Digestive Diseases

摘　　要：目的探讨胆汁中白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)对急性胆管炎(AC)诊断和严重程度判断的价值。方法42例患者经ERCP胆道插管和/或术中抽取胆汁检测IL-6、TNF-α、IL-8的表达水平。结果AC患者轻症组与重症组胆汁中IL-6、TNF-α、IL-8的表达均显著高于对照组,重症组IL-6、TNF-α高于轻症组(P<0.001),重症组IL-8高于轻症组,但其差别无统计学意义(P>0.05)。结论胆汁中TNF-α、IL-6、IL-8参与了AC发病的病理过程,对AC的明确诊断以及严重程度预测有一定的价值。Objective To determine whether the biliary levels of cytokines is valuable for diagnosis of acute cholangitis（AC） and associated with extent of AC, by measuring biliary interleukin-6 （IL-6）, interleukin-8 （IL-8）, tumor necrosis factor-α（TNF- α）in patients. Methods 42 patients undergoing ERCP or operation comprised the study group. IL-6, TNF-α, IL-8 were measured in aspirated bile using an ELISA technique. Results AC group＇s biliary IL-6, IL- 8, TNF-α were significantly higher than control group（P〈0.001）. Moreover, severe group＇s hiliary IL 6 and TNF-α were higher than mild group＇s（P〈0. 001）. Conclusions This study suggested that biliary IL-6, IL 8, TNF-α had participated inflammation reaction of AC; They could be markers for AC and useful for predicting the degree of AC.

关 键 词：急性胆管炎 急性重症胆管炎 白细胞介素-6 白细胞介素-8 肿瘤坏死因子-α 

分 类 号：R657.4[医药卫生—外科学]