四君子汤治疗精神分裂症记忆损害的临床观察  

Clinical Observation on Improving the Memory Impairment of Patients with Schizophrenia by Si Junzi Tang

作　　者：周方[1] 贾竑晓[1] 唐永怡[1] 张继志[1] 江镇康[1] 

机构地区：[1]首都医科大学附属北京安定医院

出　　处：《首都医科大学学报》2008年第4期428-430,共3页Journal of Capital Medical University

基　　金：北京市中医管理局科研基金资助项目~~

摘　　要：目的研究四君子汤治疗精神分裂症记忆损害的疗效。方法将60例精神分裂症记忆损害患者用数字表法随机配对分为中药治疗组和安慰剂组。另选30例正常人为正常对照组。中药治疗组患者在服用氯丙嗪的同时服用四君子汤,安慰剂组患者在服用氯丙嗪的同时服用安慰剂。正常对照组不用任何治疗方法。中药治疗组和安慰剂组受试者分别在入组前和研究结束时做韦氏记忆量表检测,正常对照组受试者在入组时做韦氏记忆量表测查。结果治疗组和安慰剂组受试者治疗前各记忆项目分数与正常对照组相比差异有统计学意义(P<0.01),顺数、倒数、背数、记图、再认、再生、联想、理解和MQ值治疗组治疗前后比较和与安慰剂组比较差异有统计学意义(P<0.05);积累分项目检测结果显示,治疗组治疗前后比较和与安慰剂组比较差异无统计学意义(P>0.05)。安慰剂组各记忆项目检测分数治疗前后比较差异无统计学意义(P>0.05)。结论四君子汤对精神分裂症记忆损害有一定改善作用。Objective To investigate the improving effects on memory impairment of patients with schizophrenia by Si Junzi Tang. Methods 60 patients with schizophrenia treated by chlorpromazine were divided into two groups, one was treated with herb mixture named Si Junzi Tang, and the other with placebo. WAIS memory scales and PANNS were examined before and at the end of treatment. Another 30 healthy persons as control were also examined with above memory test. Results Before treatment, the score of memory item in treatment group and placebo group was obvious lower than that of normal control group（ P 〈 0.01 ）. For score of digits forward, digits backward, number memory, figural memory, recognition, reproduction, association, comprehension, and MQ, except accumulation, obvious improvement was demonstrated in treatment group comparing with before treatment of itself and with placebo group （ P 〈 0.05 ）. While there was no difference of each memory item score before and after treatment in placebo group（P 〉 0.05 ）. Conclusion Si Junzi Tang has some improving effects on memory impairment of schizophrenic patients.

关 键 词：精神分裂症 记忆损害 中医药疗法 四君子汤 

分 类 号：R256.29[医药卫生—中医内科学]