富氧水耐缺氧和抗疲劳作用  

Studies on Enhancing Anoxia Endurance and Anti-fatigue Function of Oxygenated Water

作　　者：毕晓郁[1] 齐娜[1] 殷召雪[1] 吴金华 高丽芳[1] 曹丽歌[1] 吴涛[1] 胡子净[1] 苏忆兰[1] 陈振良[1] 

机构地区：[1]首都医科大学食品药品安全评价中心 [2]北京华意兴新技术开发研究所

出　　处：《首都医科大学学报》2008年第4期467-470,共4页Journal of Capital Medical University

基　　金：北京市优秀人才(20051D0501801)资助项目~~

摘　　要：目的研究富氧水对小鼠的耐缺氧和抗疲劳作用。方法采用灌胃法给予小鼠不同剂量的富氧水,分别测定小鼠的常压耐缺氧时间、急性脑缺血性缺氧存活时间、亚硝酸钠中毒存活时间、负重游泳时间及小鼠游泳后血清尿素氮、血乳酸、肝糖原的含量。结果富氧水低剂量组(2.4mg/kg)小鼠常压耐缺氧生存时间较对照组显著延长(P<0.05);肝糖原储备量增加(P<0.05);血乳酸上升速度减慢(P<0.05);血乳酸曲线下面积降低(P<0.05)。与对照组比较,富氧水低剂量组急性脑缺血性缺氧生存时间、亚硝酸钠中毒存活时间和负重游泳时间差异无统计学意义,但有延长的趋势;小鼠运动后血清尿素氮含量也有降低的趋势。结论富氧水具有一定耐缺氧和抗疲劳作用。Objective To investigate the effect of oxygenated water on anoxia endurance and anti-fatigue function in mice. Methods Mice were orally administered different doses of oxygenated water, survival time under anoxia, sodium nitrite poisoning or acute cerebral ischemia, loaded swimming time, serum urea nitrogen, plasma lactic acid content, and hepatic glycogen were determined. Results It was found that oxygenated water（ 2.4 mg/kg） could protract the anoxia survival time of mice under normal pressure （ P 〈 0. 05 ）. It could also significantly increase hepatic glycogen glycogen storage（ P 〈 0. 05 ） , decreased the rate of plasma lactic acid increase （ P 〈 0. 05 ） and the area under curve （AUC） of plasma lactic acid （ P 〈 0. 05 ） after exercise. Survival time under sodium nitrite poisoning or acute cerebral ischemia, loaded swimming time had the trend of prolong, the content of serum urea nitrogen also had the trend of descending. Conclusion Oxygenated water may enhance the ability of fatigue recovery and anoxia endurance function.

关 键 词：富氧水 耐缺氧 抗疲劳 小鼠 

分 类 号：R11[医药卫生—公共卫生与预防医学]