膝关节液中Ⅱ型胶原羧基端端肽含量与滑膜炎程度的关系  

Relationship Between CTX-Ⅱlevel in Synovial Fluid of Knee and Degree of Synovitis

作　　者：李正南[1] 卫小春[1] 张志强[1] 纪斌平[1] 毕树雄[1] 丁娟[1] 

机构地区：[1]山西医科大学第二附属医院骨科,太原市030001

出　　处：《中国骨与关节损伤杂志》2008年第9期734-736,共3页Chinese Journal of Bone and Joint Injury

基　　金：山西省科技攻关资助项目(2006031089-3)

摘　　要：目的探讨膝关节液中Ⅱ型胶原羧基端端肽(CTX-Ⅱ)含量与滑膜炎程度之间的关系。方法采用ELISA法对膝关节液中CTX-Ⅱ含量进行检测,并在关节镜下利用Ayral滑膜炎评分法和Outerbridge软骨损伤评分法对滑膜炎程度和软骨损伤程度进行评价。结果骨性关节炎关节液中CTX-Ⅱ含量高于非骨性关节炎OA组(t=-7.558,P<0.05);在Ayral滑膜炎评分≥60分组的关节液中CTX-Ⅱ含量高于Ayral滑膜炎评分<60分组(t=-5.113,P<0.05)。将71例膝关节疾病CTX-Ⅱ含量与Ayral滑膜炎评分呈正相关(r=0.706,P<0.05)。结论膝关节液CTX-Ⅱ含量可作为生物标记物反映关节软骨损伤累计程度外,在一定程度上还反映关节滑膜炎程度;膝关节液CTX-Ⅱ含量升高提示滑膜炎程度较重。Objective To explore the relationship between the CTX - Ⅱ level in the synovial fluid of the knee and the degree of synovitis. Methods The CTX- Ⅱlevel in the synovial fluid was measured by enzyme linked immunoassay. The degree of synovitis was assessed with Ayral＇s score system and the degree of cartilage injury with Outerbridge＇s score system under arthroscopy. Results The CTX- Ⅱ level in the synovial fluid of OA knees was higher （t = - 7.558, P〈0.05） than other knee diseases. The CTX- Ⅱ level in the synovial fluid of the knees was higher in those with Ayral＇s score≥60 than in those with the score 〈 60 （t = -5.113, P 〈 0.05）. The CTX - Ⅱ level in the synovial fluid of the knees was correlated positively with Ayral＇s score （ r = 0. 706, P 〈0.05） in 71 knees. Conclusion The CTX- Ⅱ level in the synovial fluid of the knee can reflect the degree of accumulative cartilage injury and synovitls as a biomarker, especially accumulative cartilage injury. The synovitis is more severe when the CTX - Ⅱ level in the synovial fluid of the knee is increasing.

关 键 词：骨性关节炎 CTX—Ⅱ 关节滑液 关节软骨损伤程度 滑膜炎 

分 类 号：R686.7[医药卫生—骨科学] R259.897[医药卫生—外科学]