2003年至2007年大肠埃希菌的临床分离及耐药趋势分析  

The analysis of the isolation of Escherichia coli and its resistance tendency to antimicrobial agents from 2003～2007

作　　者：肖时超 吕火祥[2] 沈蓓琼[2] 胡庆丰[2] 袁武锋[2] 

机构地区：[1]重庆市渝北区人民医院检验科,重庆渝北401120 [2]浙江省人民医院检验医学中心,浙江杭州310014

出　　处：《中国微生态学杂志》2008年第4期407-409,共3页Chinese Journal of Microecology

摘　　要：目的了解2003年至2007年大肠埃希菌在临床标本中的分离情况及其耐药趋势,为临床感染的预防和治疗提供参考资料。方法回顾分析2003年至2007年间所有标本中大肠埃希菌的分离率、标本和病区的分布构成情况以及对17种抗菌药物的耐药率。结果五年间大肠埃希菌的总分离率变化不明显,但其阳性分离率呈上升趋势,从2003年的5.02%增至2007年的6.26%;其在泌尿生殖道标本(尿液标本和尿道分泌物标本)的分离率最高(50.5%),其次是呼吸道标本(36.66%);病区分布以重症监护室最高(20.7%),其次是普外科(18.3%),所有内科病区(不含ICU)占46.6%;大肠埃希菌对12种抗菌药的耐药率大于50%,仅对其中5种的耐药率每年均低于50%。结论大肠埃希菌的临床总分离率没有明显变化,但阳性分离率有呈上升趋势,其对多数抗菌药物有较高的耐药性,所以感染的治疗应当依据抗菌药物的体外敏感试验。Objective To study the isolation of Escherichia coli （ E. coli） in the clinical specimen and its resistant tendency to antimicrobial agents from 2003 to 2007 to provide valuable data for infection prevention and treatment. Methods The isolation rates, distribution in clinical specimens and wards and the resistance rates of E. coli to 17 kinds of antimicrobi- al agents from 2003 to 2007 were reviewed. Results There was an increasing but not significant tendency of isolation rates of E. coli every year,which was 5.02% in 2003 but 6.26% in 2007. In the five years,there was a highest isolation rate of 50.50% in specimens from urogenitial system infection, the next was that from respiratory tract （36.66%） . Concerning the wards distribution,ICU had a highest rate of 20.70% ,the next was general surgery department（ 18.30% ）. And all the in- ternal medicine departments （excluding ICU） had an isolation rate of 46.60%. E. coli had resistance rates more than 50% to all the 13 kinds of antimicrobial agents, and it just had less 50% resistance rate only to 5 kinds of antimicrobial agents. Conclusion The clinical isolation rate of E. coli is increasing. It has higher resistance rates to many antimicrobial agents as well as an increasing resistance tendency to relatively susceptive antimicrobial agents every year. So physicians should prescribe on the basis of antimicrobial agents susceptibility tests in vitro.

关 键 词：大肠埃希菌 分离率 分布情况 耐药分析 

分 类 号：R378.2[医药卫生—病原生物学]