221例不稳定型心绞痛病人强化抗血小板治疗的疗效  

Combined anti-platelet treatment in 221 patients with unstable angina

作　　者：黄震华[1] 朱雅琴[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院心血管病研究室,上海200011

出　　处：《中国新药与临床杂志》2008年第8期566-569,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的比较强化抗血小板治疗和一般抗血小板治疗对不稳定型心绞痛病人的疗效。方法445例不稳定型心绞痛病人随机分为强化抗血小板治疗组和一般抗血小板治疗组。强化抗血小板治疗组(221例)联合应用氯吡格雷(75 mg,qd)和阿司匹林(100 mg,qd),一般抗血小板治疗组(224例)应用阿司匹林(100 mg,qd)。以死亡、心肌梗死、需冠状动脉内介入治疗作为主要终点。共随访2年。结果强化抗血小板治疗组13例(5.9%)达到主要终点,一般抗血小板治疗组36例(16.1%)达到主要终点。强化抗血小板治疗组主要终点发生率低于一般抗血小板治疗组(P<0.01)。结论强化抗血小板治疗可减少不稳定型心绞痛病人心血管事件的发生率。AIM To compare the efficacy of intensive anti-platelet treatment and conventional anti-platelet treatment in patients with unstable angina. METHODS Four hundred and forty-five patients with unstable angina were randomly assigned to intensive anti-platelet treatment group （intensive group） and conventional anti-platelet treatment group （conventional group）. Patients in intensive group （221 patients） were administered with clopidogrel （75 mg, qd） and aspirin （ 100 mg, qd）, while patients in conventional group （224 patients） were treated with aspirin （100 mg, qd）. The primary endpoint was death, myocardial infarction, and percutaneous coronary intervention. The follow up period was 2 years. RESULTS There were 13 （5.9 % ） patients of primary endpoint in intensive group and 36 （ 16.1% ） patients of primary endpoint in conventional group. The occurrence of primary endpoint was lower in intensive group than that in conventional group （P 〈 0.01）. CONCLUSION Intensive anti-platelet treatment could decrease the occurrence of cardiovascular event in unstable angina patients.

关 键 词：氯吡格雷 阿司匹林 心绞痛 不稳定型 

分 类 号：R541.42[医药卫生—心血管疾病] R972.3[医药卫生—内科学]